Human germline and somatic cells have similar TP53 and Kirsten-RAS gene single base mutation frequencies. (Q53037088)

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5 January 2020

title

Human germline and somatic cells have similar TP53 and Kirsten-RAS gene single base mutation frequencies (English)

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5 January 2020

2

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5 January 2020

author name string

Derek N Cole

series ordinal

1

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5 January 2020

Vincent L Wilson

series ordinal

3

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publication date

1 July 2008

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Environmental and Molecular Mutagenesis

5 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18418864%20AND%20SRC:MED&resulttype=core&format=json

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volume

49

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issue

6

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5 January 2020

page(s)

417-425

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Genetic tumor archeology: microdissection and genetic heterogeneity in squamous and basal cell carcinoma

5 January 2020

cites work

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Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis

21 January 2018

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N-Nitroso compounds in the diet

21 January 2018

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Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer

21 January 2018

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Incidence of early loss of pregnancy

21 January 2018

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Temporal delineation of sequential HPRT mutations arising in vivo in a T-cell clone with a mutator phenotype

21 January 2018

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Detection of radiation and cyclophosphamide-induced mutations in individual mouse sperm at a human expanded trinucleotide repeat locus transgene

21 January 2018

1 reference

Identification of novel TP53 mutations in familial and sporadic cancer cases of German and Swiss origin

21 January 2018

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7 January 2021

Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice

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7 January 2021

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

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7 January 2021

Flow cytometry applications in the evaluation of sperm quality: semen analysis, sperm function and DNA integrity

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7 January 2021

The origins, patterns and implications of human spontaneous mutation

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7 January 2021

Age and sex effects on human mutation rates: an old problem with new complexities

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7 January 2021

Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human

1 reference

7 January 2021

The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm

1 reference

7 January 2021

Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line

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7 January 2021

Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

To err (meiotically) is human: the genesis of human aneuploidy

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7 January 2021

The origin of human aneuploidy: where we have been, where we are going

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7 January 2021

Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases

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7 January 2021

An unexpected new role of mutant Ras: perturbation of human embryonic development

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7 January 2021

Uniparental disomy at chromosome 11p15.5 followed by HRAS mutations in embryonal rhabdomyosarcoma: lessons from Costello syndrome.

1 reference

7 January 2021

The significance of oral contraceptives in causing chromosome anomalies in spontaneous abortions

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7 January 2021

Multiple mutations and cancer

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7 January 2021

Mechanisms and consequences of paternally-transmitted chromosomal abnormalities.

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7 January 2021

The IARC TP53 database: new online mutation analysis and recommendations to users

1 reference

7 January 2021

Identification of two human sperm populations using flow and image cytometry

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7 January 2021

Evaluation of a decision aid for families considering p53 genetic counseling and testing

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7 January 2021

The molecular anatomy of spontaneous germline mutations in human testes

1 reference

7 January 2021

Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy.

1 reference

7 January 2021

Direct analysis of the chromosome constitution of human spermatozoa

1 reference

7 January 2021

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction

1 reference

7 January 2021

Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients

1 reference

7 January 2021

Major impacts of gonadal mosaicism on hereditary risk estimation, origin of hereditary diseases, and evolution.

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7 January 2021

Description of first germinal mosaic mutation identified in dominant skeletal mutation experiments and considerations about how to deal with this kind of spontaneous mutation in analyses

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7 January 2021

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models

1 reference

7 January 2021

Fertility, reproduction, and genetic disease: studies on the mutagenic effects of environmental agents on mammalian germ cells

1 reference

7 January 2021

Multicolor FISH analysis of chromosomal breaks, duplications, deletions, and numerical abnormalities in the sperm of healthy men

1 reference

7 January 2021

Frequency of human sperm carrying structural aberrations of chromosome 1 increases with advancing age.

1 reference

7 January 2021

Human Gene Mutation Database (HGMD): 2003 update.

1 reference

7 January 2021

Single base instability is promoted in vulvar lichen sclerosus.

1 reference

7 January 2021

The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect

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7 January 2021

Mendelian cytogenetics. Chromosome rearrangements associated with mendelian disorders

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7 January 2021

Germline TP53 mutations and Li-Fraumeni syndrome

1 reference

7 January 2021

GermOnline, a cross-species community knowledgebase on germ cell differentiation.

1 reference

7 January 2021

Detecting rare mutations associated with cancer risk

1 reference

7 January 2021

Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

1 reference

7 January 2021

Identifiers

DOI

10.1002/EM.20390

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18418864%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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