Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. (Q53061352)

11 May 2018

title

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. (English)

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11 May 2018

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Johanne Martel-Pelletier

11

Johanne Martel-Pelletier

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PubMed ID

24651621

11 May 2018

Jean-Pierre Pelletier

10

Jean-Pierre Pelletier

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11 May 2018

6

Hassan Fahmi

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11 May 2018

Bertrand Lussier

7

Bertrand Lussier

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11 May 2018

Faezeh Vasheghani

2

Faezeh Vasheghani

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11 May 2018

Meryem Blati

4

Meryem Blati

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11 May 2018

Peter J Roughley

8

Peter Roughley

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11 May 2018

David Lagares

9

David Lagares

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11 May 2018

author name string

Yue Zhang

1

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11 May 2018

Ying-Hua Li

3

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11 May 2018

Kayla Simeone

5

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11 May 2018

Mohit Kapoor

12

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11 May 2018

language of work or name

English

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publication date

20 March 2014

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11 May 2018

Annals of the Rheumatic Diseases

published in

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11 May 2018

volume

74

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11 May 2018

page(s)

1432-1440

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11 May 2018

issue

7

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11 May 2018

cites work

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https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

Upstream and downstream of mTOR

21 January 2018

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Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

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Autophagy fights disease through cellular self-digestion

21 January 2018

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Autophagy and the integrated stress response

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Mammalian autophagy: core molecular machinery and signaling regulation

21 January 2018

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https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model

21 January 2018

1 reference

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In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis.

21 January 2018

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.

21 January 2018

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

21 January 2018

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Cartilage in normal and osteoarthritis conditions

21 January 2018

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AMPK and mTOR in cellular energy homeostasis and drug targets

21 January 2018

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The role of autophagy during the early neonatal starvation period

21 January 2018

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Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy

21 January 2018

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mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

21 January 2018

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The role of the Atg1/ULK1 complex in autophagy regulation

21 January 2018

1 reference

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AMPK -> ULK1 -> autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204599

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

21 January 2018

1 reference

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

1 reference

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10.1136/ANNRHEUMDIS-2013-204599

21 January 2018

Identifiers

DOI

1 reference

11 May 2018

PubMed ID

24651621

1 reference

11 May 2018