Conformations of the Huntingtin N-term in aqueous solution from atomistic simulations. (Q53088567)

11 May 2018

title

Conformations of the Huntingtin N-term in aqueous solution from atomistic simulations. (English)

1 reference

11 May 2018

author

Giulia Rossetti

1

1 reference

11 May 2018

Paolo Carloni

4

1 reference

11 May 2018

Alessandro Laio

object named as

Alessandro Laio

3

0 references

author name string

Pilar Cossio

2

1 reference

11 May 2018

language of work or name

English

0 references

publication date

30 August 2011

1 reference

11 May 2018

published in

FEBS Letters

1 reference

11 May 2018

volume

585

1 reference

11 May 2018

issue

19

1 reference

11 May 2018

page(s)

3086-3089

1 reference

11 May 2018

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Huntington's disease: from molecular pathogenesis to clinical treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Flanking sequences profoundly alter polyglutamine toxicity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Polyglutamine expansion of huntingtin impairs its nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Unfolded state of peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Molecular dynamics simulations of proteins and peptides: from folding to drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Computer simulations study of biomolecules in non-aqueous or cosolvent/water mixture solutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Principles governing oligomer formation in amyloidogenic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Targeting biomolecular flexibility with metadynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

A kinetic model of trp-cage folding from multiple biased molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Development and testing of a general amber force field

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Canonical dynamics: Equilibrium phase-space distributions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

A bias-exchange approach to protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Optimizing the performance of bias-exchange metadynamics: folding a 48-residue LysM domain using a coarse-grained model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

GROMACS: A message-passing parallel molecular dynamics implementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Elucidating the folding problem of alpha-helices: local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

The Jpred 3 secondary structure prediction server

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Hierarchical analysis of conformational dynamics in biomolecules: transition networks of metastable states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Polyglutamine fibrillogenesis: the pathway unfolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

Position-dependent diffusion coefficients and free energies from Bayesian analysis of equilibrium and replica molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.08.036

10.1016/J.FEBSLET.2011.08.036

21 January 2018

Identifiers

DOI

1 reference

11 May 2018

1 reference

11 May 2018