Aqueous Extracts of Toona sinensis Leaves Inhibit Renal Carcinoma Cell Growth and Migration Through JAK2/stat3, Akt, MEK/ERK, and mTOR/HIF-2α Pathways. (Q53114366)

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scientific article published on 26 April 2016

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English	Aqueous Extracts of Toona sinensis Leaves Inhibit Renal Carcinoma Cell Growth and Migration Through JAK2/stat3, Akt, MEK/ERK, and mTOR/HIF-2α Pathways.	scientific article published on 26 April 2016

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/27115866

Aqueous Extracts of Toona sinensis Leaves Inhibit Renal Carcinoma Cell Growth and Migration Through JAK2/stat3, Akt, MEK/ERK, and mTOR/HIF-2α Pathways. (English)

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/27115866

renal carcinoma

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based on heuristic

inferred from title

object named as

Toona sinensis

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based on heuristic

inferred from title

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based on heuristic

inferred from title

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27115866%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Ling-Hui Chien

2

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4 June 2020

Bu-Miin Huang

3

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4 June 2020

Yi-Chen Chia

4

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4 June 2020

Hui-Fen Chiu

5

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publication date

26 April 2016

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PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/27115866

Nutrition and Cancer

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4 June 2020

68

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4 June 2020

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4 June 2020

654-666

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4 June 2020

Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood)

1 reference

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21 January 2018

Toona sinensis Roem (Meliaceae) leaf extract alleviates hyperglycemia via altering adipose glucose transporter 4.

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Toona sinensis (leaf extracts) inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis in vascular endothelial cells

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Toona sinensis and its major bioactive compound gallic acid inhibit LPS-induced inflammation in nuclear factor-κB transgenic mice as evaluated by in vivo bioluminescence imaging

1 reference

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Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

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Anti-Neoplastic Effects of Gallic Acid, a Major Component of Toona sinensis Leaf Extract, on Oral Squamous Carcinoma Cells

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Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells.

1 reference

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Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis

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Safety evaluation of water extracts of Toona sinensis Roemor leaf

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https://api.crossref.org/works/10.1080%2F01635581.2016.1158292

21 January 2018

Renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2016.1158292

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Estimates of the worldwide incidence of 25 major cancers in 1990.

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Biology of metastatic renal cell carcinoma

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New strategies in kidney cancer: therapeutic advances through understanding the molecular basis of response and resistance

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mTOR signaling and drug development in cancer

1 reference

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VHL and HIF signalling in renal cell carcinogenesis

1 reference

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New treatment approaches in renal cell carcinoma

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Factors affecting polyacrylamide gel electrophoresis and electroblotting of high-molecular-weight myofibrillar proteins

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c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor

1 reference

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The TRAIL apoptotic pathway in cancer onset, progression and therapy

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2016.1158292

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Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo.

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2016.1158292

21 January 2018

Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance

1 reference

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21 January 2018

Comprehensive molecular characterization of clear cell renal cell carcinoma

1 reference

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Hypoxia-induced angiogenesis: good and evil

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Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

1 reference

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In vitro and in vivo activity of gallic acid and Toona sinensis leaf extracts against HL-60 human premyelocytic leukemia

1 reference

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21 January 2018

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

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Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy

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High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers

1 reference

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21 January 2018

Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.

1 reference

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21 January 2018

p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2016.1158292

21 January 2018

Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2016.1158292

21 January 2018

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2016.1158292

21 January 2018

Akt, FoxO and regulation of apoptosis

1 reference

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21 January 2018

Downregulation of FOXO3a promotes tumor metastasis and is associated with metastasis-free survival of patients with clear cell renal cell carcinoma

1 reference

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

1 reference

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Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.

1 reference

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21 January 2018

Poor prognosis and advanced clinicopathological features of clear cell renal cell carcinoma (ccRCC) are associated with cytoplasmic subcellular localisation of Hypoxia inducible factor-2α.

1 reference

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Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells

1 reference

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21 January 2018

Identifiers

10.1080/01635581.2016.1158292

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27115866%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27115866%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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