Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy. (Q53183054)

12 May 2018

title

Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy. (English)

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12 May 2018

author name string

Yanli Cheng

1

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12 May 2018

Jingjing Zhang

2

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12 May 2018

Weiying Guo

3

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12 May 2018

Fengsheng Li

4

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12 May 2018

Weixia Sun

5

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12 May 2018

Jing Chen

6

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12 May 2018

Chi Zhang

7

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12 May 2018

Xuemian Lu

8

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12 May 2018

Yi Tan

9

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12 May 2018

Wenke Feng

10

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12 May 2018

Yaowen Fu

11

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12 May 2018

Gilbert C Liu

12

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12 May 2018

Zhonggao Xu

13

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12 May 2018

Lu Cai

14

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12 May 2018

publication date

2 February 2016

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12 May 2018

Free Radical Biology and Medicine

published in

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12 May 2018

volume

93

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12 May 2018

page(s)

94-109

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12 May 2018

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

cites work

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12 December 2020

Nrf2 activators as attractive therapeutics for diabetic nephropathy.

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12 December 2020

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

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Functional and molecular alterations of the glomerular barrier in long-term diabetes in mice

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Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?

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Fenofibrate reduces progression to microalbuminuria over 3 years in a placebo-controlled study in type 2 diabetes: results from the Diabetes Atherosclerosis Intervention Study (DAIS).

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The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling.

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PPAR-α transcriptional activity is required to combat doxorubicin-induced podocyte injury in mice

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12 December 2020

Nrf2 induces fibroblast growth factor 21 in diabetic mice

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12 December 2020

Bardoxolone methyl and kidney function in CKD with type 2 diabetes

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12 December 2020

Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation

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GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

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Type VIII collagen modulates TGF-β1-induced proliferation of mesangial cells

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Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.

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Bench-to-bench bottlenecks in translation

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Improvement of inflammatory responses associated with NF-kappa B pathway in kidneys from diabetic rats

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Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury

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12 December 2020

Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice

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12 December 2020

Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy

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12 December 2020

Fenofibrate improves renal lipotoxicity through activation of AMPK-PGC-1α in db/db mice

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12 December 2020

Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity

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12 December 2020

Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy

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12 December 2020

Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways

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12 December 2020

The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy

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12 December 2020

Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha.

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Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

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Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy

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12 December 2020

Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition

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12 December 2020

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis

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12 December 2020

Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia-reperfusion injury

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12 December 2020

Fibroblast growth factor 21 protects the heart from oxidative stress.

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12 December 2020

Long-term fenofibrate therapy increases fibroblast growth factor 21 and retinol-binding protein 4 in subjects with type 2 diabetes

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12 December 2020

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

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12 December 2020

Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model

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12 December 2020

Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance.

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12 December 2020

Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism.

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12 December 2020

Attenuation of hyperlipidemia- and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration of fibroblast growth factor-21 is associated with suppression of renal inflammation

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12 December 2020

Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2.

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12 December 2020

Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD

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12 December 2020

Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice

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12 December 2020

The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

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12 December 2020

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice

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12 December 2020

Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway

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12 December 2020

Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice

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12 December 2020

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

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12 December 2020

Kidney changes in multiparous, nulliparous and ovariectomized mice fed either a nutrient-sufficient or -deficient diet containing cadmium

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12 December 2020

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

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12 December 2020

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

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12 December 2020

Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1.

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12 December 2020

Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury

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12 December 2020

Differential effects of low-dose fenofibrate treatment in diabetic rats with early onset nephropathy and established nephropathy

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12 December 2020

10.1016/J.FREERADBIOMED.2016.02.002

Identifiers

DOI

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12 May 2018

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12 May 2018