The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. (Q53225913)

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scientific article published on 14 August 2011

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English	The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.	scientific article published on 14 August 2011

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21841778

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. (English)

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Europe PubMed Central

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12 May 2018

http://europepmc.org/abstract/MED/21841778

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author name string

Jinyi Zhang

1

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Naima Zahir

2

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Qiuhong Jiang

3

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Helen Miliotis

4

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Stephanie Heyraud

5

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Xianwang Meng

6

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Baoxia Dong

7

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Gang Xie

8

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21841778

Frank Qiu

9

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Zhenyue Hao

10

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Christopher A McCulloch

11

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Edward C Keystone

12

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Europe PubMed Central

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Alan C Peterson

13

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Katherine A Siminovitch

14

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12 May 2018

http://europepmc.org/abstract/MED/21841778

language of work or name

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publication date

14 August 2011

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Europe PubMed Central

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12 May 2018

http://europepmc.org/abstract/MED/21841778

Nature Genetics

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12 May 2018

http://europepmc.org/abstract/MED/21841778

43

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http://europepmc.org/abstract/MED/21841778

9

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http://europepmc.org/abstract/MED/21841778

902-907

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12 May 2018

http://europepmc.org/abstract/MED/21841778

https://scigraph.springernature.com/pub.10.1038/ng.904

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A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Intracellular proteinases of invertebrates: calcium-dependent and proteasome/ubiquitin-dependent systems

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Lentiviruses as gene transfer agents for delivery to non-dividing cells

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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A novel, specific interaction involving the Csk SH3 domain and its natural ligand

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Specific proteolysis of the NR2 subunit at multiple sites by calpain

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two PEST-like motifs regulate Ca2+/calpain-mediated cleavage of the CaVbeta3 subunit and provide important determinants for neuronal Ca2+ channel activity

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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A new mathematical model for relative quantification in real-time RT-PCR

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses

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https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

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A Novel Dendritic Cell-Induced Model of Erosive Inflammatory Arthritis: Distinct Roles for Dendritic Cells in T Cell Activation and Induction of Local Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

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Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21841778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21841778

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/21841778

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