Modification of the P-glycoprotein dependent pharmacokinetics of digoxin in rats by human recombinant interferon-alpha. (Q53267583)

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6 January 2020

title

Modification of the P-glycoprotein dependent pharmacokinetics of digoxin in rats by human recombinant interferon-alpha (English)

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6 January 2020

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Laurence Bonhomme-Faivre

2

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6 January 2020

author name string

Makrem Ben Reguiga

1

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6 January 2020

Simone Orbach-Arbouys

3

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6 January 2020

Robert Farinotti

4

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6 January 2020

publication date

16 August 2005

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6 January 2020

published in

Pharmaceutical Research

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6 January 2020

volume

22

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6 January 2020

issue

11

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6 January 2020

page(s)

1829-1836

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Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

6 January 2020

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11095-005-7415-5

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

21 January 2018

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12 December 2020

P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin

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12 December 2020

Pharmacokinetics of digoxin and its 4'''-acetyl- and methylderivates in the rat.

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12 December 2020

An acute toxicity study of recombinant human interferon alpha A (LBD-007) in Sprague-Dawley rats

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12 December 2020

Pharmacokinetics of digoxin administered to horses with congestive heart failure

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12 December 2020

Evaluation of MDR1, LRP, MRP, and topoisomerase IIalpha gene mRNA transcripts before and after interferon-alpha, and correlation with the mRNA expression level of the telomerase subunits hTERT and TEP1 in five unselected human melanoma cell lines.

1 reference

12 December 2020

Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity.

1 reference

12 December 2020

Effects of ketoconazole on digoxin absorption and disposition in rat.

1 reference

12 December 2020

Absorption of digoxin from the distal parts of the intestine in man

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12 December 2020

P-glycoprotein increases from proximal to distal regions of human small intestine

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12 December 2020

Plasma and tissue pharmacokinetics of human interferon-alpha in the rat after its intravenous administration

1 reference

12 December 2020

Interferon-alpha modulates resistance to cisplatin in three human hepatoma cell lines.

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12 December 2020

Pegylated interferon plus ribavirin for the treatment of chronic hepatitis C.

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12 December 2020

Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.

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12 December 2020

Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family

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12 December 2020

Interspecies scaling of interferon disposition and comparison of allometric scaling with concentration-time transformations.

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12 December 2020

Comparison of methodologies for evaluating regional intestinal permeability

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12 December 2020

Rat but not human interferons suppress hepatic oxidative drug metabolism in rats

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12 December 2020

Evaluation of the enterohepatic circulation after 3 H-digoxin administration in the rat

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12 December 2020

Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis

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12 December 2020

Differential effect of IFNalpha-2b on the cytochrome P450 enzyme system: a potential basis of IFN toxicity and its modulation by other drugs.

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12 December 2020

The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid-polycytidylic acid

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12 December 2020

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

1 reference

12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

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12 December 2020

Differential effects of recombinant interferon α on constitutive and inducible cytochrome P450 isozymes in mouse liver

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12 December 2020

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.

1 reference

12 December 2020

Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells

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12 December 2020

Interferon suppresses erythromycin metabolism in rats and human subjects

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12 December 2020

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

12 December 2020

Effect of alpha-interferon on P-glycoprotein expression and function and on verapamil modulation of doxorubicin resistance.

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12 December 2020

Pharmacokinetics of digoxin in the rat

1 reference

12 December 2020

Simple and Reliable Method for Serial Sampling of Blood from Rats

1 reference

12 December 2020

Effect of recombinant interleukin-2 pretreatment on oral and intravenous digoxin pharmacokinetics and P-glycoprotein activity in mice.

1 reference

12 December 2020

The role of P-glycoprotein in limiting intestinal regional absorption of digoxin in rats

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12 December 2020

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

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12 December 2020

Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity

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12 December 2020

Effects of Human Recombinant Interferon-α2b on P450-Dependent Isozymes in Rat Liver and Skin

1 reference

12 December 2020

Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse

1 reference

12 December 2020

Interferon-alpha 2b modulation of doxorubicin sensitivity in a multidrug resistant cell line.

1 reference

12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

12 December 2020

Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.

1 reference

12 December 2020

Permeability modulation of human intestinal Caco-2 cell monolayers by interferons

1 reference

12 December 2020

Inhibition of the intestinal digoxin absorption and exsorption by quinidine

1 reference

12 December 2020

Pharmacokinetics of digoxin and main metabolites/derivatives in healthy humans.

1 reference

12 December 2020

Alpha interferon has no effect on lidocaine metabolism in the rat.

1 reference

12 December 2020

Instability of Digoxin in Acid Medium Using a Nonisotopic Method

1 reference

12 December 2020

The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug

1 reference

12 December 2020

10.1007/S11095-005-7415-5

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16151670%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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