Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis (Q53294910)

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scientific article published on October 16, 2010

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English	Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis	scientific article published on October 16, 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis (English)

1 reference

10.1016/J.INTIMP.2010.10.005

https://api.crossref.org/works/10.1016/J.INTIMP.2010.10.005

5 August 2024

author name string

Kenji Chiba

1

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Hirotoshi Kataoka

2

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Noriyasu Seki

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Kyoko Shimano

4

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Mamoru Koyama

5

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Atsushi Fukunari

6

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Kunio Sugahara

7

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Takahisa Sugita

8

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

language of work or name

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20955831

5 August 2024

publication date

16 October 2010

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

full work available at URL

https://api.elsevier.com/content/article/PII:S1567576910003188?httpAccept=text/xml

1 reference

10.1016/J.INTIMP.2010.10.005

https://api.crossref.org/works/10.1016/J.INTIMP.2010.10.005

5 August 2024

https://api.elsevier.com/content/article/PII:S1567576910003188?httpAccept=text/plain

1 reference

10.1016/J.INTIMP.2010.10.005

https://api.crossref.org/works/10.1016/J.INTIMP.2010.10.005

5 August 2024

International Immunopharmacology

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

11

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

366-372

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

31 May 2024

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Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

1

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FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

2

1 reference

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FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

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The immune modulator FTY720 targets sphingosine 1-phosphate receptors

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

5

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

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Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

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Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

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Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus

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Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.

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S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress

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Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment

12

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Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

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FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis

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Oral fingolimod (FTY720) for relapsing multiple sclerosis

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Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results

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A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

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IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.

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Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate.

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Identifiers

10.1016/J.INTIMP.2010.10.005

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/20955831

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