Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. (Q53302969)

13 May 2018

title

Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. (English)

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13 May 2018

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8

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13 May 2018

author name string

Ken Miyoshi

1

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13 May 2018

Mikiro Takaishi

2

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13 May 2018

Kimiko Nakajima

3

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13 May 2018

Mitsunori Ikeda

4

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13 May 2018

Takashi Kanda

5

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13 May 2018

Masahito Tarutani

6

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13 May 2018

Tatsuo Iiyama

7

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13 May 2018

John DiGiovanni

9

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13 May 2018

Shigetoshi Sano

10

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13 May 2018

language of work or name

English

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publication date

2 September 2010

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13 May 2018

Journal of Investigative Dermatology

published in

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13 May 2018

volume

131

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13 May 2018

issue

1

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13 May 2018

page(s)

108-117

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13 May 2018

Interleukin 20: discovery, receptor identification, and role in epidermal function

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IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

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Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation

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Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis

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Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

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Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

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Identification of Cellular Pathways of "Type 1," Th17 T Cells, and TNF- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells in Autoimmune Inflammation through Pharmacogenomic Study of Cyclosporine A in Psoriasis

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A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

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Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

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Stat3 and Stat4 direct development of IL-17-secreting Th cells.

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

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Cracking the cytokine code in psoriasis

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Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases

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Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors

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Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium

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Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol.

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The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

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7 January 2021

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

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Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases

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Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation.

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Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

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7 January 2021

Effect of 1 alpha,25-dihydroxyvitamin D3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions

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7 January 2021

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

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7 January 2021

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7 January 2021

Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice.

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7 January 2021

IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression

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7 January 2021

Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37

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7 January 2021

Development, cytokine profile and function of human interleukin 17-producing helper T cells

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7 January 2021

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not.

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7 January 2021

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

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7 January 2021

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

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7 January 2021

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

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7 January 2021

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

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7 January 2021

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

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7 January 2021

Identifiers

DOI

10.1038/JID.2010.255

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13 May 2018

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13 May 2018