B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis. (Q53321121)

13 May 2018

title

B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis. (English)

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13 May 2018

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6

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13 May 2018

author name string

I Sobczak

1

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13 May 2018

G Galabova-Kovacs

2

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13 May 2018

I Sadzak

3

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13 May 2018

A Kren

4

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13 May 2018

G Christofori

5

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13 May 2018

language of work or name

English

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publication date

19 May 2008

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13 May 2018

published in

Oncogene

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13 May 2018

volume

27

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13 May 2018

issue

35

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13 May 2018

page(s)

4779-4787

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/onc.2008.128

exact match

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cites work

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

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cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells

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Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis

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Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance

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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

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Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

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Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

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ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.

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BRAF mutation predicts sensitivity to MEK inhibition

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Identification of fibroblast heterogeneity in the tumor microenvironment

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Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

31 March 2020

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Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

31 March 2020

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The RAF proteins take centre stage

31 March 2020

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Pericytes limit tumor cell metastasis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2008.128

1 reference

13 May 2018

PubMed ID

18490924

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13 May 2018