Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase. (Q53330219)

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3 January 2020

title

Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase (English)

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3 January 2020

1

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3 January 2020

David A Gillespie

series ordinal

4

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3 January 2020

author name string

E J Black

series ordinal

2

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3 January 2020

G Zachos

series ordinal

3

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language of work or name

English

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publication date

6 August 2007

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3 January 2020

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3 January 2020

volume

27

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3 January 2020

issue

7

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3 January 2020

page(s)

896-906

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210702

3 January 2020

exact match

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cites work

Chk1 and Chk2 kinases in checkpoint control and cancer

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

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Chk1 in the DNA damage response: conserved roles from yeasts to mammals

21 January 2018

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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

21 January 2018

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

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The CHEK2 gene and inherited breast cancer susceptibility

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The G2-phase DNA-damage checkpoint

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SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

21 January 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

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Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1).

21 January 2018

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Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase

21 January 2018

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Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

21 January 2018

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

21 January 2018

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

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Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation

21 January 2018

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Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

21 January 2018

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Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

21 January 2018

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Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

21 January 2018

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Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors

21 January 2018

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