Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. (Q53331692)

13 May 2018

title

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. (English)

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13 May 2018

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hepatocellular carcinoma

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Desnoyers LR

1

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13 May 2018

Pai R

2

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13 May 2018

Ferrando RE

3

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13 May 2018

Hötzel K

4

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13 May 2018

Le T

5

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13 May 2018

Ross J

6

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13 May 2018

Carano R

7

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13 May 2018

D'Souza A

8

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13 May 2018

Qing J

9

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13 May 2018

Mohtashemi I

10

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13 May 2018

Ashkenazi A

11

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13 May 2018

French DM

12

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13 May 2018

language of work or name

English

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publication date

25 June 2007

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13 May 2018

published in

Oncogene

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13 May 2018

volume

27

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13 May 2018

issue

1

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13 May 2018

page(s)

85-97

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210623

exact match

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Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

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FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease

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Cellular signaling by fibroblast growth factor receptors

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The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

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Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes

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Amplification of fgfr4 gene in human breast and gynecological cancers

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Fibroblast growth factors in cancer: therapeutic possibilities

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Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis

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FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells

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A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

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Fibroblast growth factors

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Receptor specificity of the fibroblast growth factor family

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Fibroblast growth factors, their receptors and signaling

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Cytoplasmic expression of fibroblast growth factor receptor-4 in human pituitary adenomas: relation to tumor type, size, proliferation, and invasiveness

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Common and distinct elements in cellular signaling via EGF and FGF receptors

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Identification of a new fibroblast growth factor receptor, FGFR5

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Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma

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The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression

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FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

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FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

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Fibroblast growth factor receptor (FGFR) 4 correlated with the malignancy of human astrocytomas.

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Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids

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Functional FGFR4 Gly388Arg Polymorphism Predicts Prognosis in Lung Adenocarcinoma Patients

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High-throughput tissue microarray analysis of 11q13 gene amplification (CCND1, FGF3, FGF4, EMS1) in urinary bladder cancer

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Precancerous changes in the human liver

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PDGF alpha- and beta-receptors activate unique and common signal transduction pathways

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Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer

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FGF4 and INT2 oncogenes are amplified and expressed in Kaposi's sarcoma

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CT depiction of experimental liver tumors: contrast enhancement with hepatocyte-selective iodinated triglyceride versus conventional techniques

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Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high‐grade soft tissue sarcoma

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210623

1 reference

13 May 2018

PubMed ID

17599042

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13 May 2018