CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. (Q53369015)

13 May 2018

title

CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. (English)

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13 May 2018

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6

Paul R Sanberg

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Richard Flavell

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object named as

Richard A Flavell

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13 May 2018

author name string

Kirk P Townsend

1

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13 May 2018

Terrence Town

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13 May 2018

Takashi Mori

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Lih-Fen Lue

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Doug Shytle

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David Morgan

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Francisco Fernandez

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Jun Tan

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language of work or name

English

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publication date

1 March 2005

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13 May 2018

European Journal of Immunology

published in

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13 May 2018

volume

35

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issue

3

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page(s)

901-910

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13 May 2018

Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation

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Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease

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Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications

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TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Amyloid β protein deposition and neuron loss in osteopetrotic (op/op) mice

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Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

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Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.

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Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases

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Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury

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Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells

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7 January 2021

MHC class II and CD40 play opposing roles in dendritic cell survival.

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7 January 2021

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis

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7 January 2021

Complement component C1q modulates the phagocytosis of Abeta by microglia

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Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.

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MHC class II-positive microglia in human brain: association with Alzheimer lesions

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Modulation of MHC class II expression in the absence of lymphocytic infiltrates in Alzheimer's retinae.

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Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy

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Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation

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Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells

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Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases

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7 January 2021

Developmental plasticity of CNS microglia

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7 January 2021

Regulating factors for microglial activation

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7 January 2021

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils.

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7 January 2021

A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

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7 January 2021

Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

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7 January 2021

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

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7 January 2021

CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes

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7 January 2021

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.

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7 January 2021

CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway

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7 January 2021

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

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7 January 2021

Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor

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7 January 2021

Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis

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7 January 2021

Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42).

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200425585

7 January 2021

Identifiers

DOI

10.1002/EJI.200425585

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13 May 2018

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13 May 2018