Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. (Q53376636)

13 May 2018

title

Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. (English)

1 reference

13 May 2018

author

Angustias Page

3

1 reference

13 May 2018

David G. Johnson

7

1 reference

13 May 2018

author name string

Thomas R Berton

1

1 reference

13 May 2018

Takashi Matsumoto

2

1 reference

13 May 2018

Claudio J Conti

4

1 reference

13 May 2018

Chu-Xia Deng

5

1 reference

13 May 2018

José L Jorcano

6

1 reference

13 May 2018

language of work or name

English

0 references

publication date

1 August 2003

1 reference

13 May 2018

published in

Oncogene

1 reference

13 May 2018

volume

22

1 reference

13 May 2018

issue

35

1 reference

13 May 2018

page(s)

5415-5426

1 reference

13 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206825

exact match

0 references

cites work

BRCA1-associated growth arrest is RB-dependent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

Evidence for a transcriptional activation function of BRCA1 C-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

BRCA1 regulates p53-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

BRCA1 is a cell cycle-regulated nuclear phosphoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

Regulation of BRCA1 expression by the Rb-E2F pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

BRCA1 interacts with components of the histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Transcriptional activation by BRCA1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information Core

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

p53 mutations in BRCA1-associated familial breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

p53 involvement in BRCA1-associated breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

BRCA1 mutations in primary breast and ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

BRCA1 required for transcription-coupled repair of oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

BRCA1 carries tumor suppressor activity distinct from that of p53 and p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

BRCA1 is a component of the RNA polymerase II holoenzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

1 reference

7 January 2021

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Localization of BRCA1 and a splice variant identifies the nuclear localization signal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Loss of heterozygosity (LOH) atp53 is correlated with LOH atBRCA1 andBRCA2 in various human malignant tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206825

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206825

1 reference

13 May 2018

1 reference

13 May 2018