Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues. (Q53409221)

14 May 2018

title

Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues. (English)

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14 May 2018

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P Upadhyaya

1

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S G Carmella

series ordinal

2

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F P Guengerich

series ordinal

3

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S S Hecht

series ordinal

4

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14 May 2018

language of work or name

English

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publication date

1 June 2000

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published in

Carcinogenesis

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volume

21

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issue

6

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page(s)

1233-1238

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Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke.

cites work

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines

21 January 2018

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Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Tobacco smoke carcinogens and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Absolute configuration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol formed metabolically from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Solvolysis of model compounds for alpha-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Characterization of a glucuronide metabolite of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Mammalian carbonyl reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Stereospecific reduction of haloperidol in human tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Species differences in the chirality of the carbonyl reduction of [14C] fenofibrate in laboratory animals and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

The identification of 11 beta-hydroxysteroid dehydrogenase as carbonyl reductase of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.5.233

21 January 2018

Identifiers

DOI

10.1093/CARCIN/21.5.233

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14 May 2018

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14 May 2018