EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy. (Q53538486)

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scientific article published on 23 July 2007

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English	EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.	scientific article published on 23 July 2007

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2 January 2020

EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy (English)

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2 January 2020

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2 January 2020

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Y-N Fu

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2 January 2020

C-L Yeh

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2 January 2020

H H-Y Cheng

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C-H Yang

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2 January 2020

S-F Tsai

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S-F Huang

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23 July 2007

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957-965

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2 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210684

0 references

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c-Src and cooperating partners in human cancer

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications.

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Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

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21 January 2018

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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21 January 2018

Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumors

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21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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21 January 2018

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

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21 January 2018

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

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Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.

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Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

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Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

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21 January 2018

Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

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21 January 2018

SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines

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21 January 2018

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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21 January 2018

Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung cancer

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7 January 2021

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