Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. (Q53571283)

15 May 2018

title

Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. (English)

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15 May 2018

main subject

phase I clinical trial

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11

Christof von Kalle

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Elke Will

1

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Jeff Bailey

2

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Todd Schuesler

3

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15 May 2018

Ute Modlich

4

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Brenden Balcik

5

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15 May 2018

Ben Burzynski

6

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15 May 2018

David Witte

7

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Gerlinde Layh-Schmitt

8

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15 May 2018

Cornelia Rudolph

9

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Brigitte Schlegelberger

10

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Christopher Baum

12

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Brian P Sorrentino

13

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Lars M Wagner

14

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15 May 2018

Patrick Kelly

15

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Lilith Reeves

16

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David A Williams

17

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publication date

13 February 2007

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15 May 2018

published in

Molecular Therapy

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15 May 2018

volume

15

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15 May 2018

page(s)

782-791

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15 May 2018

issue

4

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15 May 2018

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

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7 January 2021

Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells

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7 January 2021

In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations

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7 January 2021

Detection of ecotropic replication-competent retroviruses: comparison of s(+)/l(-) and marker rescue assays

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7 January 2021

Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose.

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Stem cell collection and gene transfer in Fanconi anemia

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Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy

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7 January 2021

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

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7 January 2021

POTENTIATION OF VIRUS LEUKAEMOGENESIS IN C57BL MICE BY X-IRRADIATION OR URETHANE.

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7 January 2021

Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice

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7 January 2021

Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population

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7 January 2021

Plat-E: an efficient and stable system for transient packaging of retroviruses

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7 January 2021

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

1 reference

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7 January 2021

Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300083

7 January 2021

Comparison of five retrovirus vectors containing the human IL-2 receptor gamma chain gene for their ability to restore T and B lymphocytes in the X-linked severe combined immunodeficiency mouse model.

1 reference

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7 January 2021

Real-Time PCR: an Effective Tool for Measuring Transduction Efficiency in Human Hematopoietic Progenitor Cells

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7 January 2021

Tumor cells escape suicide gene therapy by genetic and epigenetic instability

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7 January 2021

Cytogenetic characteristics of a murine in vitro model for the human anaplastic large cell lymphoma (ALCL).

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300083

1 reference

15 May 2018

PubMed ID

17299409

1 reference

15 May 2018