Dose-escalation study of ICA-17043 in patients with sickle cell disease. (Q53591605)

16 May 2018

title

Dose-escalation study of ICA-17043 in patients with sickle cell disease. (English)

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16 May 2018

4

Elliott P Vichinsky

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16 May 2018

Kenneth I Ataga

1

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Eugene P Orringer

2

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Lori Styles

3

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Paul Swerdlow

5

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George A Davis

6

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Philip A Desimone

7

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Jonathan W Stocker

8

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language of work or name

English

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publication date

1 November 2006

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16 May 2018

published in

Pharmacotherapy

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volume

26

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issue

11

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16 May 2018

page(s)

1557-1564

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16 May 2018

Delay time of hemoglobin S polymerization prevents most cells from sickling in vivo

cites work

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Kinetics and Mechanism of Deoxyhemoglobin S Gelation: A New Approach to Understanding Sickle Cell Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

The function of calcium in the potassium permeability of human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Elevated Erythrocyte Calcium in Sickle Cell Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Effects of deoxygenation on active and passive Ca2+ transport and on the cytoplasmic Ca2+ levels of sickle cell anemia red cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Inhibition of the in vitro formation of dense cells and of irreversibly sickled cells by charybdotoxin, a specific inhibitor of calcium-activated potassium efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Stochastic nature and red cell population distribution of the sickling-induced Ca2+ permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Mode of action and comparative efficacy of pharmacological agents that inhibit calcium-dependent dehydration of sickle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1592%2FPHCO.26.11.1557

21 January 2018

Identifiers

DOI

10.1592/PHCO.26.11.1557

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16 May 2018

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16 May 2018