Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension. (Q53622979)

16 May 2018

title

Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension. (English)

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16 May 2018

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Laimute Taraseviciene-Stewart

1

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16 May 2018

Robertas Scerbavicius

2

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Kang-Hyeon Choe

3

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Carlyne Cool

4

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Kathy Wood

5

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Rubin M Tuder

6

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Nana Burns

7

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Michael Kasper

8

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Norbert F Voelkel

9

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publication date

12 May 2006

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16 May 2018

American Journal of Physiology - Lung Cellular and Molecular Physiology

published in

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16 May 2018

volume

291

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16 May 2018

issue

4

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16 May 2018

page(s)

L668-76

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Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth

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Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth

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DA-8159, a potent cGMP phosphodiesterase inhibitor, attenuates monocrotaline-induced pulmonary hypertension in rats

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Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling

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Simvastatin induces caspase-independent apoptosis in LPS-activated RAW264.7 macrophage cells

21 January 2018

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Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death.

21 January 2018

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Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors

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Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs

21 January 2018

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Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension

21 January 2018

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Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.

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Caveolin-1 expression enhances endothelial capillary tubule formation

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Apoptosis and lung injury.

21 January 2018

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Statins and their role in vascular protection

21 January 2018

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Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

21 January 2018

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Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

21 January 2018

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21 January 2018

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Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.

21 January 2018

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40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats

21 January 2018

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Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells.

21 January 2018

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HIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study

21 January 2018

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Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span†

21 January 2018

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Pulmonary arterial hypertension: thin-section CT predictors of epoprostenol therapy failure

21 January 2018

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Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

21 January 2018

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21 January 2018

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A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model

21 January 2018

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Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy.

21 January 2018

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The pathobiology of pulmonary hypertension. Endothelium

21 January 2018

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Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00491.2005

10.1152/AJPLUNG.00491.2005

21 January 2018

Identifiers

DOI

1 reference

16 May 2018

PubMed ID

16698853

1 reference

16 May 2018