PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent. (Q53686626)

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26 March 2020

title

PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent (English)

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Qingkai Yang

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author name string

Lina Wang

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Xiaoyan Wu

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Kai Wang

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Dan Xie

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Qi Xiao

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Songyu Li

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Kui Jiang

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Lujian Liao

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John R Yates

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Jiing-Dwan Lee

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language of work or name

English

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publication date

7 May 2018

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volume

78

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issue

10

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26 March 2020

page(s)

2475-2489

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PML, a growth suppressor disrupted in acute promyelocytic leukemia

26 March 2020

cites work

1 reference

12 December 2020

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

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Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

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PML is essential for multiple apoptotic pathways

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The transcriptional role of PML and the nuclear body

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

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Specific interaction of PML bodies with the TP53 locus in Jurkat interphase nuclei

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CDC25B mediates rapamycin-induced oncogenic responses in cancer cells.

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

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Mutation in TET2 in myeloid cancers

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A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia

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12 December 2020

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

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12 December 2020

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery.

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12 December 2020

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

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12 December 2020

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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12 December 2020

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

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12 December 2020

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

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12 December 2020

Cancer epigenetics reaches mainstream oncology

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12 December 2020

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

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12 December 2020

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

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12 December 2020

The expansive reach of TET2

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12 December 2020

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

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12 December 2020

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

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12 December 2020

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

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12 December 2020

The origin and evolution of mutations in acute myeloid leukemia

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12 December 2020

BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction

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12 December 2020

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

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12 December 2020

SnapShot: Acute myeloid leukemia

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12 December 2020

TET2 promotes histone O-GlcNAcylation during gene transcription

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12 December 2020

Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A.

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12 December 2020

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

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12 December 2020

Interplay between the cancer genome and epigenome

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12 December 2020

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

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12 December 2020

Differential Roles of PML Isoforms

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12 December 2020

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

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12 December 2020

Mutational landscape and significance across 12 major cancer types

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12 December 2020

TET enzymes, TDG and the dynamics of DNA demethylation.

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12 December 2020

Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins

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12 December 2020

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

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12 December 2020

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation

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12 December 2020

PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia

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12 December 2020

Genomic Classification and Prognosis in Acute Myeloid Leukemia

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12 December 2020

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

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12 December 2020

IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC.

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12 December 2020

Targeting BMK1 Impairs the Drug Resistance to Combined Inhibition of BRAF and MEK1/2 in Melanoma

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12 December 2020

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

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12 December 2020

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.

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12 December 2020

10.1158/0008-5472.CAN-17-3091

Identifiers

DOI

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26 March 2020

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26 March 2020

PubMed publication ID

29735542

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