Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants. (Q54045457)

24 May 2018

title

Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants. (English)

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24 May 2018

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Timothy E. Hardingham

6

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24 May 2018

author name string

Fosang AJ

1

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24 May 2018

Last K

2

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24 May 2018

Stanton H

3

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24 May 2018

Weeks DB

4

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24 May 2018

Campbell IK

5

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24 May 2018

Hembry RM

7

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24 May 2018

language of work or name

English

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publication date

1 October 2000

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24 May 2018

Journal of Biological Chemistry

published in

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24 May 2018

volume

275

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24 May 2018

issue

42

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24 May 2018

page(s)

33027-33037

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24 May 2018

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

21 January 2018

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ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family

21 January 2018

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Mechanism of catabolism of aggrecan by articular cartilage

21 January 2018

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Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan.

21 January 2018

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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

21 January 2018

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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

21 January 2018

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Aggrecan degradation in human intervertebral disc and articular cartilage

21 January 2018

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Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

21 January 2018

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

21 January 2018

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Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain

21 January 2018

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Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis

21 January 2018

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Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids

21 January 2018

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21 January 2018

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Biochemical characterization of human collagenase-3

21 January 2018

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The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity

21 January 2018

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A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures.

21 January 2018

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Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein

21 January 2018

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Passive loss of proteoglycan from articular cartilage explants

21 January 2018

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Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid

21 January 2018

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Degradation of proteoglycan in articular cartilage

21 January 2018

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Variations in the composition of bovine hip articular cartilage with distance from the articular surface

21 January 2018

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Proteoglycan aggregate formation by articular chondrocytes. Decrease in link-protein synthesis during culture

21 January 2018

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Effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in cartilage explants

21 January 2018

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Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope

21 January 2018

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Turnover of proteoglycans in guinea pig costal cartilage

21 January 2018

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Hyaluronan-binding region of aggrecan from pig laryngeal cartilage. Amino acid sequence, analysis of N-linked oligosaccharides and location of the keratan sulphate

21 January 2018

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N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage

21 January 2018

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Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity

21 January 2018

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Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage

21 January 2018

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The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

21 January 2018

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Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis

21 January 2018

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Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis

21 January 2018

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Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

21 January 2018

1 reference

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Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction

21 January 2018

1 reference

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Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis

21 January 2018

1 reference

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Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M910207199

Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M910207199

Electrophoresis of 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M910207199

Changes in cartilage composition and physical properties due to stromelysin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M910207199

21 January 2018

Identifiers

DOI

10.1074/JBC.M910207199

1 reference

24 May 2018

PubMed ID

10882746

1 reference

24 May 2018