Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. (Q54117225)

25 May 2018

title

Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. (English)

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25 May 2018

main subject

multiple drug resistance

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Yamane Y

1

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25 May 2018

Furuichi M

2

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Song R

3

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Van NT

4

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25 May 2018

Mulcahy RT

5

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Ishikawa T

6

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Kuo MT

7

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25 May 2018

language of work or name

English

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publication date

1 November 1998

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25 May 2018

Journal of Biological Chemistry

published in

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volume

273

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issue

47

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25 May 2018

page(s)

31075-31085

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25 May 2018

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

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The ATP-dependent glutathione S-conjugate export pump

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ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids

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ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene.

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Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.

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ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

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Glutathione and related enzymes in multidrug resistance

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Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase

21 January 2018

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Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues

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Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells

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Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues

21 January 2018

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Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

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Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

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Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

21 January 2018

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Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression

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On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

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Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance

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The role of thiols in mitochondrial susceptibility to iron and tert-butyl hydroperoxide-mediated toxicity in cultured mouse hepatocytes

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Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

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Glutathione metabolism.

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Differential effects of depleting agents on cytoplasmic and nuclear non-protein sulphydryls: a fluorescence image cytometry study

21 January 2018

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Bcl-2 expression causes redistribution of glutathione to the nucleus

21 January 2018

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Demonstration of nuclear compartmentalization of glutathione in hepatocytes

21 January 2018

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Activation of the OxyR transcription factor by reversible disulfide bond formation

21 January 2018

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Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression

21 January 2018

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Biology of the multidrug resistance-associated protein, MRP.

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Redox signalling and the control of cell growth and death

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.47.31075

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25 May 2018

PubMed ID

9813007

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25 May 2018