A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. (Q54118067)

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scientific article published in November 1998

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English	A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.	scientific article published in November 1998

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scholarly article

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. (English)

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Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

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author name string

Jansen G

1

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Mauritz R

2

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Drori S

3

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Sprecher H

4

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Kathmann I

5

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Bunni M

6

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Priest DG

7

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Noordhuis P

8

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Schornagel JH

9

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Pinedo HM

10

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Peters GJ

11

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Assaraf YG

12

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http://europepmc.org/abstract/MED/9804775

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publication date

1 November 1998

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Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

Journal of Biological Chemistry

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Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

273

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http://europepmc.org/abstract/MED/9804775

46

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http://europepmc.org/abstract/MED/9804775

30189-30198

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Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

The cellular pharmacology of methotrexate

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Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells

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Molecular cloning of the human placental folate transporter

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Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake

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Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells

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A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

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Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

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A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

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Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds

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Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells

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Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity

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Identifiers

10.1074/JBC.273.46.30189

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

1 reference

Europe PubMed Central

25 May 2018

http://europepmc.org/abstract/MED/9804775

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