Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase. (Q54400236)

29 May 2018

title

Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase. (English)

1 reference

29 May 2018

1 reference

Daniel Flores

1

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29 May 2018

Lorenzo Battini

series ordinal

2

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29 May 2018

G Luca Gusella

series ordinal

3

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29 May 2018

Rajeev Rohatgi

series ordinal

4

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29 May 2018

publication date

23 November 2010

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29 May 2018

published in

The Nephron Journals

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29 May 2018

volume

117

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29 May 2018

issue

4

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29 May 2018

page(s)

p27-36

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29 May 2018

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

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Collective cell migration drives morphogenesis of the kidney nephron

4 June 2018

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Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes

4 June 2018

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Clinical manifestations of hereditary cystic kidney disease

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Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts

4 June 2018

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Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1

4 June 2018

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Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

4 June 2018

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Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

4 June 2018

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Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

4 June 2018

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Regulation of cation transport in the distal nephron by mechanical forces

4 June 2018

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Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells

4 June 2018

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Molecular basis of the effects of shear stress on vascular endothelial cells

4 June 2018

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Pathogenetic mechanisms of diabetic nephropathy

4 June 2018

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Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90.

4 June 2018

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Two populations of node monocilia initiate left-right asymmetry in the mouse

4 June 2018

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Removal of the MDCK cell primary cilium abolishes flow sensing

4 June 2018

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

4 June 2018

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

4 June 2018

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Bending the MDCK cell primary cilium increases intracellular calcium

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997441

Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997441

Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases

4 June 2018

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Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways

4 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997441

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium

4 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997441

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression

4 June 2018

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Adult polycystic kidney disease: Studies of the defect in urine concentration

4 June 2018

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The clinical utility of renal concentrating capacity in polycystic kidney disease.

4 June 2018

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Cystic renal diseases in children

4 June 2018

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Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts

4 June 2018

1 reference

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Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases

13 August 2018

1 reference

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Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance.

13 August 2018

1 reference

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Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells

13 August 2018

1 reference

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Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis

13 August 2018

1 reference

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Luminal flow induces eNOS activation and translocation in the rat thick ascending limb

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997441

Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct

13 August 2018

1 reference

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Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct

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Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells

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Adaptive changes of juxtamedullary glomerular filtration in the remnant kidney

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Mechanoregulation of intracellular Ca2+ in human autosomal recessive polycystic kidney disease cyst-lining renal epithelial cells

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Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects

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MAP kinase activation by flow in endothelial cells. Role of beta 1 integrins and tyrosine kinases

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High urine volume and low urine osmolality are risk factors for faster progression of renal disease

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Identifiers

DOI

10.1159/000321640

1 reference

29 May 2018

PMCID

2997441

1 reference

29 May 2018

PubMed ID

21109758

1 reference

29 May 2018