Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex. (Q54434334)

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7 January 2020

title

Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex (English)

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7 January 2020

1

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7 January 2020

Theo Wallimann

5

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7 January 2020

author name string

Marianne Suter

2

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7 January 2020

Roland Tuerk

3

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7 January 2020

Uwe Riek

4

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7 January 2020

publication date

1 July 2007

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7 January 2020

published in

Molecular Biotechnology

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7 January 2020

volume

36

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issue

3

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7 January 2020

page(s)

220-231

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https://scigraph.springernature.com/pub.10.1007/s12033-007-0029-x

7 January 2020

exact match

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cites work

A molecular approach to the concerted action of kinases involved in energy homoeostasis

2 references

Crossref

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21 January 2018

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AMP-activated protein kinase: balancing the scales.

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Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

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Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

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12 December 2020

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

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12 December 2020

LKB1-dependent signaling pathways

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12 December 2020

The LKB1 tumor suppressor negatively regulates mTOR signaling

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12 December 2020

Protein production by auto-induction in high density shaking cultures

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12 December 2020

TSC2 mediates cellular energy response to control cell growth and survival

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12 December 2020

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

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12 December 2020

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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12 December 2020

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

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12 December 2020

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

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12 December 2020

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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12 December 2020

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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12 December 2020

An efficient expression system for the production of functionally active human LKB1.

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12 December 2020

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

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12 December 2020

A set of pBR322-compatible plasmids allowing the testing of chaperone-assisted folding of proteins overexpressed in Escherichia coli

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12 December 2020

Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol

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12 December 2020

Analysis of the LKB1-STRAD-MO25 complex

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12 December 2020

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

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12 December 2020

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

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12 December 2020

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.

1 reference

12 December 2020

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

1 reference

12 December 2020