Dangerous duet: LRRK2 and α-synuclein jam at CMA. (Q54441670)

29 May 2018

title

Dangerous duet: LRRK2 and α-synuclein jam at CMA. (English)

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29 May 2018

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Zhenyu Yue

1

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29 May 2018

X William Yang

series ordinal

2

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language of work or name

English

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publication date

1 April 2013

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29 May 2018

published in

Nature Neuroscience

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volume

16

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issue

4

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page(s)

375-377

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Interplay of LRRK2 with chaperone-mediated autophagy

cites work

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Chaperone-mediated autophagy: a unique way to enter the lysosome world

21 January 2018

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Recent advances in the genetics of Parkinson's disease

21 January 2018

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

21 January 2018

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The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity

21 January 2018

1 reference

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

1 reference

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

1 reference

Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications

21 January 2018

1 reference

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

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Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

21 January 2018

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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

21 January 2018

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

21 January 2018

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Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

21 January 2018

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Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23528933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NN.3361

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