Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex. (Q54468633)

30 May 2018

title

Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex. (English)

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30 May 2018

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Ian N Foltz

1

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Sylvia Hu

2

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Chadwick King

3

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Xinle Wu

4

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Chaofeng Yang

5

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Wei Wang

6

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Jennifer Weiszmann

7

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Jennitte Stevens

8

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Jiyun Sunny Chen

9

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Noi Nuanmanee

10

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Jamila Gupte

11

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Renee Komorowski

12

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Laura Sekirov

13

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Todd Hager

14

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Taruna Arora

15

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Hongfei Ge

16

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Helene Baribault

17

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30 May 2018

Fen Wang

18

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Jackie Sheng

19

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Margaret Karow

20

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Minghan Wang

21

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Yongde Luo

22

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Wallace McKeehan

23

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Zhulun Wang

24

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Murielle M Véniant

25

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Yang Li

26

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language of work or name

English

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publication date

1 November 2012

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30 May 2018

Science Translational Medicine

published in

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30 May 2018

volume

4

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30 May 2018

page(s)

162ra153

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issue

162

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30 May 2018

Hormone-like fibroblast growth factors and metabolic regulation

cites work

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

21 January 2018

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Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis

21 January 2018

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

21 January 2018

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betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

21 January 2018

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FGF21 N- and C-termini play different roles in receptor interaction and activation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

21 January 2018

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

21 January 2018

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism

21 January 2018

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FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

21 January 2018

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21 January 2018

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21 January 2018

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Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

21 January 2018

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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

21 January 2018

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FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals

21 January 2018

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Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress

21 January 2018

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10.1126/SCITRANSLMED.3004690

21 January 2018

Identifiers

DOI

1 reference

30 May 2018

PubMed ID

23197570

1 reference

30 May 2018