Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes. (Q54548112)

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English	Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes.	scientific article

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2 January 2020

Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes (English)

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2 January 2020

toll-like receptor

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5

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author name string

Hyemi Kim

1

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2 January 2020

Eunjung Yang

2

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2 January 2020

Jeonggi Lee

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2 January 2020

Se-Hoon Kim

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Joo Young Park

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2 January 2020

Sun Ju Choi

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2 January 2020

Se Jong Kim

8

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In-Hong Choi

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publication date

31 January 2008

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124

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2 January 2020

480-488

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4

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2 January 2020

Toll-like receptors and Type I interferons

1 reference

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25 August 2018

The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA.

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TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5

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Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages

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Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the Toll-like receptor 3.

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Microglia recognize double-stranded RNA via TLR3.

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Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators.

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TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression.

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Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes

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25 August 2018

Preferential expression and function of Toll-like receptor 3 in human astrocytes

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Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

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25 August 2018

mRNA is an endogenous ligand for Toll-like receptor 3.

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25 August 2018

Subcellular localization of Toll-like receptor 3 in human dendritic cells

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25 August 2018

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

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25 August 2018

Toll-like receptors

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25 August 2018

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

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25 August 2018

Broad expression of Toll-like receptors in the human central nervous system

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Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

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Multiple signaling cascades are differentially involved in gene induction by double stranded RNA in interferon-alpha-primed cells.

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The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS

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10.1111/J.1365-2567.2007.02799.X

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2 January 2020

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