Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. (Q54562272)

1 June 2018

title

Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. (English)

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1 June 2018

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Yinan Hua

1

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1 June 2018

Yingmei Zhang

2

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1 June 2018

Asli F Ceylan-Isik

3

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1 June 2018

Loren E Wold

4

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1 June 2018

Jennifer M Nunn

5

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1 June 2018

Jun Ren

6

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1 June 2018

publication date

9 September 2011

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1 June 2018

Basic Research in Cardiology

published in

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1 June 2018

volume

106

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1 June 2018

issue

6

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1 June 2018

page(s)

1173-1191

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1 June 2018

https://scigraph.springernature.com/pub.10.1007/s00395-011-0222-8

exact match

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cites work

Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Loss of cardioprotection with ageing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Blockage of angiotensin II type 2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Autophagy and aging: the importance of maintaining "clean" cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Role of autophagy in heart failure associated with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3beta/mTOR signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Cardioprotection requires taking out the trash

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

mTOR's role in ageing: protein synthesis or autophagy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Autophagy regulates ageing in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Selective autophagy mediated by autophagic adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Developmental changes of β-galactosidase and β-glucuronidase in the rat liver and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Cardiovascular aging research: the next horizons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Effects of chronic Akt activation on glucose uptake in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Cardiac regulation by phosphoinositide 3-kinases and PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

The FoxO family in cardiac function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Myocardial aging and senescence: where have the stem cells gone?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Autophagy in the heart and liver during normal aging and calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Views from within and beyond: narratives of cardiac contractile dysfunction under senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: slayer or savior?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0222-8

10.1007/S00395-011-0222-8

21 January 2018

Identifiers

DOI

1 reference

1 June 2018

PubMed ID

21901288

1 reference

1 June 2018