Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. (Q54593894)

1 June 2018

title

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. (English)

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5

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author name string

J Kirchheiner

1

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H Schmidt

2

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M Tzvetkov

3

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J-T H A Keulen

4

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I Roots

6

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J Brockmöller

7

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publication date

4 July 2006

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The Pharmacogenomics Journal

published in

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volume

7

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page(s)

257-265

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issue

4

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https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500406

exact match

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Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan

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Impact of the CYP2D6 ultra-rapid metabolizer genotype on doxepin pharmacokinetics and serotonin in platelets

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Impact of the CYP2D6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers

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Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics

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Molecular diversity at the CYP2D6 locus in the Mediterranean region

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Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers

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Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension

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Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

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Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

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A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine

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Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

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Quantification of the O- and N-demethylated and the glucuronidated metabolites of codeine relative to the debrisoquine metabolic ratio in urine in ultrarapid, rapid, and poor debrisoquine hydroxylators

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Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence.

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Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

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Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes

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Plasma concentrations of codeine and its metabolite, morphine, after single and repeated oral administration

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Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6

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PCR-based genotyping for duplicated and deleted CYP2D6 genes

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The role of active metabolites in dihydrocodeine effects

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Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity

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7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500406

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1 June 2018

PubMed ID

16819548

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1 June 2018