SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23). (Q54602756)

1 June 2018

title

SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23). (English)

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1 June 2018

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acute myeloid leukemia

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1

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Carla Pinto

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Manuel R. Teixeira

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Susana Lisboa

object named as

S Lisboa

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Cecilia Correia

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C Correia

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author name string

S Bizarro

3

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1 June 2018

J M Mariz

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M Marques

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language of work or name

English

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publication date

8 May 2006

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1 June 2018

published in

Oncogene

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1 June 2018

volume

25

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1 June 2018

issue

45

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1 June 2018

page(s)

6147-6152

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1 June 2018

Translocation and gross deletion breakpoints in human inherited disease and cancer I: Nucleotide composition and recombination-associated motifs

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The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

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A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15.

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Translocation and gross deletion breakpoints in human inherited disease and cancer II: Potential involvement of repetitive sequence elements in secondary structure formation between DNA ends

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The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis.

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The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14)

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Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures

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FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23).

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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

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New insight into the molecular mechanisms of MLL-associated leukemia

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t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

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MLL targets SET domain methyltransferase activity to Hox gene promoters

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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

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MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

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Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia

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Topoisomerase II inhibitor-related acute myeloid leukaemia

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One short well conserved region of Alu-sequences is involved in human gene rearrangements and has homology with prokaryotic chi.

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Do septins have a role in cancer?

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Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints

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When epigenetics kills: MLL fusion proteins in leukemia

21 January 2018

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EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

21 January 2018

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MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

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A mitotic septin scaffold required for Mammalian chromosome congression and segregation

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The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).

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The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis

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AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

21 January 2018

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

21 January 2018

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Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia

21 January 2018

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Translocation 2;11 and other significant chromosome changes in acute monoblastic leukemia (M5) with clonal evolution: sequential clinical and cytogenetic studies

21 January 2018

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7 January 2021

Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants

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7 January 2021

Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML

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7 January 2021

Chromosome abnormalities and MLL rearrangements in acute myeloid leukemia of infants

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Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209626

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1 June 2018

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1 June 2018