3D-QSAR and docking studies on pyrazolo[4,3-h]qinazoline-3-carboxamides as cyclin-dependent kinase 2 (CDK2) inhibitors (Q54647850)

2 June 2018

title

3D-QSAR and docking studies on pyrazolo[4,3-h]qinazoline-3-carboxamides as cyclin-dependent kinase 2 (CDK2) inhibitors (English)

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.08.131

20 July 2024

author name string

Ping Lan

1

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2 June 2018

Wan-Na Chen

2

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2 June 2018

Gao-Keng Xiao

3

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2 June 2018

Ping-Hua Sun

4

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2 June 2018

Wei-Min Chen

5

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2 June 2018

language of work or name

English

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publication date

24 September 2010

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2 June 2018

full work available at URL

number of pages

9

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based on heuristic

inferred from page(s)

https://api.elsevier.com/content/article/PII:S0960894X10012679?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.08.131

https://api.elsevier.com/content/article/PII:S0960894X10012679?httpAccept=text/plain

20 July 2024

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.08.131

Bioorganic & Medicinal Chemistry Letters

20 July 2024

published in

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2 June 2018

volume

20

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issue

22

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page(s)

6764-6772

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2 June 2018

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

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Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors

20 July 2024

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Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor

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5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity

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Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.

20 July 2024

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Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors

20 July 2024

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Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues.

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Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors

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3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors

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Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity

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Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

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Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

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3D-QSAR study of 8-azabicyclo[3.2.1] octane analogs antagonists of cholinergic receptor.

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3D QSAR studies on ketoamides of human cathepsin K inhibitors based on two different alignment methods

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Docking and 3D-QSAR studies of 7-hydroxycoumarin derivatives as CK2 inhibitors

20 July 2024

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Docking-based 3D-QSAR study of HIV-1 integrase inhibitors.

20 July 2024

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3D-QSAR and docking studies on transforming growth factor (TGF)-beta receptor 1 antagonists.

20 July 2024

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3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors

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Molecular modeling studies of Rho kinase inhibitors using molecular docking and 3D-QSAR analysis.

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Docking and 3D-QSAR studies of BMS-806 analogs as HIV-1 gp120 entry inhibitors

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3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N-myristoyltransferase inhibitors

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain

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Receptor- and ligand-based 3D-QSAR study for a series of non-nucleoside HIV-1 reverse transcriptase inhibitors.

20 July 2024

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Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases.

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3D-QSAR and docking studies of aminopyridine carboxamide inhibitors of c-Jun N-terminal kinase-1.

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20 July 2024

Identifiers

1 reference

2 June 2018

1 reference

2 June 2018