Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. (Q54770022)

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English	Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2.	scientific article

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Europe PubMed Central

PubMed publication ID

3 June 2018

http://europepmc.org/abstract/MED/19177593

Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. (English)

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Europe PubMed Central

PubMed publication ID

3 June 2018

http://europepmc.org/abstract/MED/19177593

Jacques Pouysségur

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Jacques Pouysségur

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3 June 2018

http://europepmc.org/abstract/MED/19177593

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Christophe Frémin

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Anne Bessard

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http://europepmc.org/abstract/MED/19177593

Frédéric Ezan

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3 June 2018

http://europepmc.org/abstract/MED/19177593

Luc Gailhouste

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http://europepmc.org/abstract/MED/19177593

Morgane Régeard

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Jacques Le Seyec

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http://europepmc.org/abstract/MED/19177593

David Gilot

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Gilles Pagès

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http://europepmc.org/abstract/MED/19177593

Sophie Langouët

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Georges Baffet

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1 March 2009

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3 June 2018

http://europepmc.org/abstract/MED/19177593

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3 June 2018

http://europepmc.org/abstract/MED/19177593

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930-939

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3 June 2018

http://europepmc.org/abstract/MED/19177593

Liver cell models in in vitro toxicology

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The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes

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PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

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Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice

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The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.

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An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway

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Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

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The role of erk1 and erk2 in multiple stages of T cell development.

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The MAP kinase pathway is required for entry into mitosis and cell survival.

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The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis

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MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells

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Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G.

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Identifiers

10.1002/HEP.22730

1 reference

Europe PubMed Central

PubMed publication ID

3 June 2018

http://europepmc.org/abstract/MED/19177593

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 June 2018

http://europepmc.org/abstract/MED/19177593

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