TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy. (Q54962340)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720451%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

title

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720451%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

main subject

anti-retroviral agent

0 references

0 references

2

1 reference

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25 March 2020

Peter T. Hraber

3

1 reference

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25 March 2020

So-Yon Lim

1

1 reference

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25 March 2020

Jeffrey M Gerold

5

1 reference

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25 March 2020

Tiffany L Barnes

6

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25 March 2020

Srisowmya Sanisetty

7

1 reference

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25 March 2020

Michael S Seaman

8

1 reference

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25 March 2020

Mark G. Lewis

9

1 reference

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25 March 2020

Alison L Hill

14

1 reference

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25 March 2020

James B Whitney

15

1 reference

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25 March 2020

12

Tomas Cihlar

1 reference

25 March 2020

Joe Hesselgesser

4

1 reference

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25 March 2020

Romas Geleziunas

10

1 reference

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25 March 2020

Michael D Miller

11

1 reference

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25 March 2020

William A Lee

13

1 reference

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25 March 2020

language of work or name

English

0 references

publication date

1 May 2018

1 reference

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Science Translational Medicine

25 March 2020

published in

1 reference

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25 March 2020

volume

10

1 reference

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25 March 2020

issue

439

1 reference

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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

25 March 2020

cites work

1 reference

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16 June 2018

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16 June 2018

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16 June 2018

1 reference

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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses

16 June 2018

1 reference

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GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees

16 June 2018

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Optimization and qualification of an 8-color intracellular cytokine staining assay for quantifying T cell responses in rhesus macaques for pre-clinical vaccine studies

16 June 2018

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16 June 2018

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Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors

16 June 2018

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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

16 June 2018

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Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells

16 June 2018

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Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

16 June 2018

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Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir

16 June 2018

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Genital tract sequestration of SIV following acute infection

16 June 2018

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Eradication therapies for HIV Infection: time to begin again

16 June 2018

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Estimating time since infection in early homogeneous HIV-1 samples using a poisson model

16 June 2018

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Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation

16 June 2018

1 reference

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The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial

16 June 2018

1 reference

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Mechanisms of HIV latency: an emerging picture of complexity

16 June 2018

1 reference

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Combinatorial latency reactivation for HIV-1 subtypes and variants

16 June 2018

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CD16- natural killer cells: enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection

16 June 2018

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Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection

16 June 2018

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T-cell vaccination reduces simian immunodeficiency virus levels in semen

16 June 2018

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A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression

16 June 2018

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Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid

16 June 2018

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Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

16 June 2018

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16 June 2018

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Mamu-B*08-positive macaques control simian immunodeficiency virus replication

16 June 2018

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The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication

16 June 2018

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16 June 2018

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16 June 2018

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Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication

16 June 2018

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16 June 2018

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A nonhuman primate model for the selective elimination of CD8+ lymphocytes using a mouse-human chimeric monoclonal antibody.

16 June 2018

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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

16 June 2018

1 reference

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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

16 June 2018

1 reference

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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

16 June 2018

1 reference

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Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods

16 June 2018

1 reference

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The general stochastic model of nucleotide substitution

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5973480

Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5973480

Development and homeostasis of T cell memory in rhesus macaque

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5973480

Roles for CXC chemokine ligands 10 and 11 in recruiting CD4+ T cells to HIV-1-infected monocyte-derived macrophages, dendritic cells, and lymph nodes

13 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29720451

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAO4521

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720451%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29720451%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

1 reference