Growth differentiation factor 5 (Q5513078)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

radotermin
LAP-4
cartilage-derived morphogenetic protein-1
bone morphogenetic protein 14
lipopolysaccharide-associated protein 4
LPS-associated protein 4
BMP-14
Cartilage-derived morphogenetic protein 1
GDF5
CDMP-1
growth/differentiation factor 5

Language	Label	Description	Also known as
English	Growth differentiation factor 5	mammalian protein found in Homo sapiens	radotermin LAP-4 cartilage-derived morphogenetic protein-1 bone morphogenetic protein 14 lipopolysaccharide-associated protein 4 LPS-associated protein 4 BMP-14 Cartilage-derived morphogenetic protein 1 GDF5 CDMP-1 growth/differentiation factor 5

Statements

1 reference

13 November 2019

UniProt protein ID

Transforming growth factor-beta-related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43026

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43026

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

protein binding

determination method

5 references

8 April 2019

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

identical protein binding

determination method

1 reference

8 April 2019

Biophysical and structural characterization of a folded core domain within the proregion of growth and differentiation factor-5

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

transforming growth factor beta receptor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

growth factor activity

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

biological process

regulation of apoptotic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

negative regulation of neuron apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

forelimb morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

negative regulation of mesenchymal cell apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

regulation of MAPK cascade

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

SMAD protein signal transduction

determination method

2 references

27 March 2018

Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43026&geneProductId=UniProtKB:P43026

determination method

27 March 2018

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43026&geneProductId=UniProtKB:P43026

determination method

chondrocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

cell development

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

regulation of multicellular organism growth

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

hindlimb morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

chondroblast differentiation

determination method

1 reference

8 April 2019

Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

cartilage development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

negative regulation of chondrocyte differentiation

determination method

1 reference

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

transmembrane receptor protein serine/threonine kinase signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

embryonic limb morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

positive regulation of chondrocyte differentiation

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

positive regulation of neuron differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

negative regulation of epithelial cell proliferation

determination method

1 reference

8 April 2019

Bone morphogenetic proteins and growth and differentiation factors in the human cornea

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

positive regulation of BMP signaling pathway

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

response to mechanical stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

ossification involved in bone remodeling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

regulation of SMAD protein signal transduction

determination method

1 reference

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

BMP signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

SMAD protein signal transduction

determination method

3 references

8 April 2019

Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

determination method

Gene Atlas image

PBB GE GDF5 206614 at fs.png
732 × 530; 12 KB

0 references

Transforming growth factor-beta, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43026

TGF-beta, propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43026

Transforming growth factor beta, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43026

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363489

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363489

ENSP00000363492

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363492

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q5513078&oldid=2022907958"