Glucagon like peptide 1 receptor (Q5572289)

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mammalian protein found in Homo sapiens

• seven transmembrane helix receptor
• GLP-1 receptor
• GLP1 receptor
• glucagon-like peptide 1 receptor
• GLP1R
• uniprot:P43220

edit

Language	Label	Description	Also known as
English	Glucagon like peptide 1 receptor	mammalian protein found in Homo sapiens	seven transmembrane helix receptor GLP-1 receptor GLP1 receptor glucagon-like peptide 1 receptor GLP1R uniprot:P43220

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P43220

part of

GPCR, family 2, glucagon-like peptide-1 receptor

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P43220

GPCR family 2, extracellular hormone receptor domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P43220

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.4.6

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2-like

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2, secretin-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P43220

encoded by

GLP1R

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P43220

molecular function

G protein-coupled peptide receptor activity

determination method

IEA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

determination method

IEA

G protein-coupled receptor activity

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

signal transducer activity

determination method

IEA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

determination method

IEA

protein binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IPI

glucagon receptor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

transmembrane signaling receptor activity

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

glucagon-like peptide 1 receptor activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IDA

G protein-coupled peptide receptor activity

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IBA

peptide hormone binding

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IBA

cell component

integral component of membrane

determination method

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

membrane

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

plasma membrane

determination method

TAS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

TAS

retrieved

8 April 2019

stated in

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

intracellular anatomical structure

determination method

IEA

1 reference

retrieved

10 September 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

determination method

IEA

integral component of plasma membrane

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IDA

biological process

regulation of heart contraction

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

regulation of insulin secretion

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

TAS

positive regulation of cytosolic calcium ion concentration

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IDA

cellular response to glucagon stimulus

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

activation of adenylate cyclase activity

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

TAS

cell surface receptor signaling pathway

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

positive regulation of blood pressure

determination method

IEA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

determination method

IEA

learning or memory

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

cAMP-mediated signaling

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IDA

signal transduction

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IDA

G protein-coupled receptor signaling pathway

determination method

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P43220

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

response to psychosocial stress

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

positive regulation of blood pressure

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

determination method

IBA

physically interacts with

tirzepatide

object has role

agonist

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL4297839

dulaglutide

object has role

agonist

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL2108027

Gene Atlas image

PBB GE GLP1R 208401 s at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P43220

1 reference

stated in

Identifiers.org

has part(s)

GPCR, family 2-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P43220

GPCR, family 2, extracellular hormone receptor domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P43220

GPCR, family 2, secretin-like, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P43220

Identifiers

MeSH descriptor ID

D000067757

subject named as

Glucagon-Like Peptide-1 Receptor

0 references

MeSH tree code

D12.776.543.750.695.021.500

0 references

D12.776.543.750.750.360.100.500

0 references

RefSeq protein ID

NP_002053

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2740

XP_016866239

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2740

XP_016866240

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2740

UniProt protein ID

P43220

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P43220

Ensembl protein ID

ENSP00000362353

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000362353

PDB structure ID

3C59

1 reference

stated in

UniProt

UniProt protein ID

P43220

retrieved

9 August 2016

language of work or name

English

3C5T

1 reference

stated in

UniProt

UniProt protein ID

P43220

retrieved

9 August 2016

language of work or name

English

3IOL

1 reference

stated in

UniProt

UniProt protein ID

P43220

retrieved

9 August 2016

language of work or name

English

4ZGM

1 reference

stated in

UniProt

UniProt protein ID

P43220

retrieved

9 August 2016

language of work or name

English

Transporter Classification Database ID

9.A.14.4.6

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

UMLS CUI

C0378073

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q5572289&oldid=2098114352"