PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home (Q55919570)

Expert Opinion on Investigational Drugs

Europe PubMed Central

title

PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home (English)

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Andrew N Billin

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language of work or name

English

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publication date

22 September 2008

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published in

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volume

17

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issue

10

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page(s)

1465-1471

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cites work

PPAR delta as a therapeutic target in metabolic disease.

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

New therapeutic target for metabolic syndrome: PPARdelta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Emerging roles of PPARdelta in metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

PPAR delta agonists and metabolic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Peroxisome proliferator-activated receptor-delta, a regulator of oxidative capacity, fuel switching and cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

PPAR delta: a dagger in the heart of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Activation of PPARdelta alters lipid metabolism in db/db mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

The PPARs: from orphan receptors to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Transcriptional repression of atherogenic inflammation: modulation by PPARdelta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

The peroxisome proliferator activated receptor delta is required for the differentiation of THP-1 monocytic cells by phorbol ester

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

PPARdelta regulates glucose metabolism and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Safety issues and prospects for future generations of PPAR modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

The next generation of PPAR drugs: do we have the tools to find them?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

The withdrawal of torcetrapib from drug development: implications for the future of drugs that alter HDL metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

PPARbeta/delta selectively induces differentiation and inhibits cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465

Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.17.10.1465