heme oxygenase 1 (Q5631153)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09601

Haem oxygenase-like, multi-helical

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09601

Haem oxygenase conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Protein HMOX1 PDB 1n3u.png
867 × 586; 406 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

phospholipase D activity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

protein homodimerization activity

1 reference

26 September 2017

Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

heme oxygenase (decyclizing) activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

6 references

26 September 2017

26 September 2017

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

1 reference

26 September 2017

signal transducer activity

1 reference

26 September 2017

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

heme binding

2 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

protein binding

IPI

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

1 reference

26 September 2017

cell component

cytosol

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

1 reference

26 September 2017

nucleolus

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

endoplasmic reticulum

Human heme oxygenase cDNA and induction of its mRNA by hemin

6 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

caveola

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

perinuclear region of cytoplasm

1 reference

26 September 2017

Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

extracellular space

1 reference

26 September 2017

Decidual expression and maternal serum levels of heme oxygenase 1 are increased in pre-eclampsia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of neuron apoptotic process

biological process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

1 reference

26 September 2017

cellular response to heat

1 reference

26 September 2017

Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of mast cell cytokine production

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

response to hypoxia

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

excretion

IC

1 reference

26 September 2017

Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

low-density lipoprotein particle clearance

IC

1 reference

26 September 2017

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

small GTPase mediated signal transduction

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of DNA binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

response to nicotine

1 reference

26 September 2017

Differential induction of heme oxygenase-1 against nicotine-induced cytotoxicity via the PI3K, MAPK, and NF-kappa B pathways in immortalized and malignant human oral keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

iron ion homeostasis

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

2 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of mast cell degranulation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

cellular response to cadmium ion

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

regulation of angiogenesis

1 reference

26 September 2017

Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of muscle cell apoptotic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of DNA-binding transcription factor activity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

cellular response to nutrient

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

positive regulation of angiogenesis

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

response to estrogen

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

wound healing involved in inflammatory response

1 reference

26 September 2017

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

regulation of blood pressure

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

heme catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

3 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

26 September 2017

Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

erythrocyte homeostasis

1 reference

26 September 2017

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

cellular response to arsenic-containing substance

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

26 September 2017

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

endothelial cell proliferation

1 reference

26 September 2017

Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

26 September 2017

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

smooth muscle hyperplasia

1 reference

26 September 2017

The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

protein homooligomerization

1 reference

26 September 2017

Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of leukocyte migration

1 reference

26 September 2017

Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

cellular response to hypoxia

IEP

1 reference

26 September 2017

Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of cell population proliferation

IEP

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

heme metabolic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

positive regulation of smooth muscle cell proliferation

1 reference

26 September 2017

BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

regulation of transcription from RNA polymerase II promoter in response to iron

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

positive regulation of apoptotic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

cellular response to cisplatin

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

positive regulation of macroautophagy

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of vascular associated smooth muscle cell proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of epithelial cell apoptotic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

liver regeneration

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

negative regulation of macroautophagy

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601

physically interacts with

Viroporin 3a

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

BioGRID

Family with sequence similarity 209 member A

Haem oxygenase conserved site

two-hybrid screening

0 references

Gene Atlas image

PBB GE HMOX1 203665 at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09601

Identifiers

MeSH descriptor ID

D051547

subject named as

Heme Oxygenase-1

0 references

MeSH tree code

D08.811.682.690.708.410.500

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023