Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus (Q56342513)

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scientific article published on 24 September 2018

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English	Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus	scientific article published on 24 September 2018

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scholarly article

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15 April 2020

Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus (English)

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15 April 2020

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Jean A Bernatchez

1

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15 April 2020

8

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15 April 2020

author name string

Zunhua Yang

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15 April 2020

Michael Coste

3

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15 April 2020

Jerry Li

4

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Sungjun Beck

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Yan Liu

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15 April 2020

Alex E Clark

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15 April 2020

Lucas A Luna

9

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Christal D Sohl

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Byron W Purse

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Rongshi Li

12

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15 April 2020

Jair L Siqueira-Neto

13

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24 September 2018

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15 April 2020

Antimicrobial Agents and Chemotherapy

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15 April 2020

62

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15 April 2020

AAC.00725-18

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10

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15 April 2020

on focus list of Wikimedia project

WikiProject Zika Corpus

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Zika virus disease-associated Guillain-Barré syndrome-Barranquilla, Colombia 2015-2016.

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2 November 2018

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly.

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2 November 2018

Cell-line dependent antiviral activity of sofosbuvir against Zika virus

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2 November 2018

Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae

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2 November 2018

Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice

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2 November 2018

High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.

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2 November 2018

Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals

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2 November 2018

Opportunities and challenges in phenotypic drug discovery: an industry perspective

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2 November 2018

Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics

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2 November 2018

Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

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2 November 2018

The Race To Find Antivirals for Zika Virus

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2 November 2018

Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2'-modified nucleotide analogues

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2 November 2018

Analysis of Ribonucleotide 5’ -Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-dependent RNA Polymerase Using Non-Radioactive Polymerase Assays

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2 November 2018

Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay

1 reference

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2 November 2018

Zika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an FDA-approved library

1 reference

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2 November 2018

The FDA-approved drug sofosbuvir inhibits Zika virus infection

1 reference

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2 November 2018

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase

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2 November 2018

Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus

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2 November 2018

Zika Virus Replicons for Drug Discovery

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2 November 2018

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

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2 November 2018

Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities

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2 November 2018

Nucleoside inhibitors of Zika virus

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2 November 2018

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

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2 November 2018

The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

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2 November 2018

Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

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2 November 2018

Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products

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2 November 2018

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III).

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2 November 2018

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (II).

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2 November 2018

Structure-activity relationships and design of viral mutagens and application to lethal mutagenesis

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2 November 2018

HIV-1 reverse transcriptase and antiviral drug resistance. Part 1.

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2 November 2018

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I)

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2 November 2018

Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine.

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2 November 2018

Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents

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2 November 2018

Therapeutically targeting RNA viruses via lethal mutagenesis

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2 November 2018

Aryloxy phosphoramidate triesters as pro-tides

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2 November 2018

Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Identifiers

10.1128/AAC.00725-18

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15 April 2020

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Europe PubMed Central

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15 April 2020

1 reference

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15 April 2020

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