The fundamental role of epigenetic events in cancer (Q56421597)

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

31 March 2020

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DNA hypermethylation in tumorigenesis: epigenetics joins genetics

31 March 2020

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Cancer epigenetics comes of age

31 March 2020

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Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

31 March 2020

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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

31 March 2020

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Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

31 March 2020

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Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

31 March 2020

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Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

31 March 2020

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Gene-Expression Profiles in Hereditary Breast Cancer

31 March 2020

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Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

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31 March 2020

Chasing the cancer demon

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Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer

31 March 2020

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DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

31 March 2020

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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

31 March 2020

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hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis

31 March 2020

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p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

31 March 2020

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Methylation profiling of CpG islands in human breast cancer cells

31 March 2020

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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

31 March 2020

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Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis

31 March 2020

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Molecular basis of base substitution hotspots in Escherichia coli

31 March 2020

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

31 March 2020

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Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer

31 March 2020

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Hypomethylation distinguishes genes of some human cancers from their normal counterparts

31 March 2020

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Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

31 March 2020

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

31 March 2020

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The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

31 March 2020

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Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16

31 March 2020

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DNA hypomethylation leads to elevated mutation rates

31 March 2020

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Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.

31 March 2020

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DNA methylation directs a time-dependent repression of transcription initiation.

31 March 2020

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Chromosomal silencing and localization are mediated by different domains of Xist RNA.

31 March 2020

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Cellular differentiation, cytidine analogs and DNA methylation

31 March 2020

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Heterochromatin Dynamics in Mouse Cells

31 March 2020

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Histone acetylation and transcriptional regulatory mechanisms

31 March 2020

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Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases

31 March 2020

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Methylation-induced repression--belts, braces, and chromatin

31 March 2020

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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

31 March 2020

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MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

31 March 2020

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Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

31 March 2020

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Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

31 March 2020

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CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

31 March 2020

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Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production

31 March 2020

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Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.

31 March 2020

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Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression

31 March 2020

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Translating the Histone Code

31 March 2020

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

31 March 2020

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Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

31 March 2020

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Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries

31 March 2020

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Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

31 March 2020

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A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

31 March 2020

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Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase

31 March 2020

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

31 March 2020

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Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation

31 March 2020

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Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

31 March 2020

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Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation

31 March 2020

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The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

31 March 2020

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Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

31 March 2020

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Role of DNA 5-methylcytosine transferase in cell transformation by fos

31 March 2020

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Suppression of intestinal neoplasia by DNA hypomethylation.

31 March 2020

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DNA methyltransferase Dnmt1 associates with histone deacetylase activity

31 March 2020

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DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

31 March 2020

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DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

31 March 2020

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Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

31 March 2020

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Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

31 March 2020

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Duplication and maintenance of heterochromatin domains

31 March 2020

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Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

31 March 2020

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

31 March 2020

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CpG methylation is maintained in human cancer cells lacking DNMT1.

31 March 2020

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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

31 March 2020

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DNA hypomethylation can activate Xist expression and silence X-linked genes.

31 March 2020

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Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

31 March 2020

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Putting boundaries on silence

31 March 2020

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Formation of methylation patterns in the mammalian genome

31 March 2020

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Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

31 March 2020

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Aging, DNA methylation and cancer

31 March 2020

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The biology of cancer metastasis or, ?you cannot fix it if you do not know how it works?

31 March 2020

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In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

31 March 2020

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Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrest

31 March 2020

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

31 March 2020

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The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

31 March 2020

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Biological effects of 5-azacytidine in eukaryotes

31 March 2020

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Studies of X chromosome DNA methylation in normal human cells

31 March 2020

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Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation

31 March 2020

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Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues

31 March 2020

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

31 March 2020

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Roles of cell division and gene transcription in the methylation of CpG islands.

31 March 2020

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Emerging molecular markers of cancer.

31 March 2020

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Tumour class prediction and discovery by microarray-based DNA methylation analysis

31 March 2020

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