Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (Q56565594)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

title

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (English)

1 reference

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30 August 2019

main subject

visceral leishmaniasis

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1

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30 August 2019

Manu De Rycker

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30 August 2019

Michael D. Urbaniak

8

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30 August 2019

Thomas D Otto

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30 August 2019

Fabio Zuccotto

14

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30 August 2019

Sébastien Albrecht

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30 August 2019

David W. Gray

23

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30 August 2019

Susan A Dixon

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30 August 2019

Michael J. Ferguson

28

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30 August 2019

Alan Fairlamb

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30 August 2019

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Nadine Homeyer

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30 August 2019

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Laste Stojanovski

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30 August 2019

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Matt Berriman

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30 August 2019

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Paul G Wyatt

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Timothy J Miles

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Kevin D Read

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Ian H Gilbert

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30 August 2019

4

Sabrinia Crouch

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30 August 2019

6

Rhiannon Lowe

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30 August 2019

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Stephanie Gresham

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30 August 2019

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Sujatha Manthri

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30 August 2019

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Hannah Pflaumer

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30 August 2019

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Markus Boesche

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30 August 2019

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Lalitha Sastry

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30 August 2019

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Sonja Ghidelli-Disse

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30 August 2019

13

Lorna M MacLean

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30 August 2019

26

Jose M Fiandor

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30 August 2019

author name string

Michael Thomas

2

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30 August 2019

Stephen Patterson

3

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30 August 2019

Paul Connolly

19

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30 August 2019

Gerard Drewes

22

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30 August 2019

Frederick R C Simeons

11

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30 August 2019

language of work or name

English

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publication date

25 July 2018

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30 August 2019

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30 August 2019

volume

560

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30 August 2019

issue

7717

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30 August 2019

page(s)

192-197

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https://scigraph.springernature.com/pub.10.1038/s41586-018-0356-z

30 August 2019

exact match

0 references

cites work

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7 January 2021

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7 January 2021

Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use

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7 January 2021

Developments in the treatment of visceral leishmaniasis

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Unresponsiveness to AmBisome in some Sudanese patients with kala-azar.

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7 January 2021

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

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7 January 2021

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

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7 January 2021

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

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7 January 2021

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

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7 January 2021

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

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7 January 2021

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

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7 January 2021

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

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7 January 2021

Target deconvolution strategies in drug discovery

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From noncovalent to covalent bonds: a paradigm shift in target protein identification

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7 January 2021

Target identification for biologically active small molecules using chemical biology approaches

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7 January 2021

Hide and seek: Identification and confirmation of small molecule protein targets

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Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages.

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7 January 2021

Rational design of inhibitors that bind to inactive kinase conformations

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7 January 2021

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

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7 January 2021

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

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7 January 2021

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

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7 January 2021

Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei

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7 January 2021

The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.

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7 January 2021

Pairwise knockdowns of cdc2-related kinases (CRKs) in Trypanosoma brucei identified the CRKs for G1/S and G2/M transitions and demonstrated distinctive cytokinetic regulations between two developmental stages of the organism

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7 January 2021

Optimized chemical proteomics assay for kinase inhibitor profiling.

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7 January 2021

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

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7 January 2021

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

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The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei

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7 January 2021

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7 January 2021

Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

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7 January 2021

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PubMed

https://pubmed.ncbi.nlm.nih.gov/30046105

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41586-018-0356-Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30046105%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference