Structural Basis for Possible Calcium-Induced Activation Mechanisms of Calpains (Q56591899)

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author name string

S. Strobl

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C. Fernandez-Catalan

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K. Suzuki

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W. Bode

Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence

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publication date

5 January 2001

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published in

Biological Chemistry

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volume

382

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issue

5

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cites work

1 reference

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Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

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Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes

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The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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Calpain: a protease in search of a function?

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The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains

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Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

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A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution

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Roles of individual EF-hands in the activation of m-calpain by calcium

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The role of the calpain-calpastatin system in thyrotropin-releasing hormone-induced selective down-regulation of a protein kinase C isozyme, nPKC epsilon, in rat pituitary GH4C1 cells

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

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Calcium triggers an intramolecular association of the C2 domains in synaptotagmin

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Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?

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Degradation of transcription factors, c-Jun and c-Fos, by calpain

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Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation

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Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain.

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Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease

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Calpains: intact and active?

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Structure of papain refined at 1.65 A resolution

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Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system.

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Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding

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Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain

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Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene

21 January 2018

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The C2 domain calcium-binding motif: structural and functional diversity

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Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A

21 January 2018

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Calpainopathy-a survey of mutations and polymorphisms

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C2-domains, structure and function of a universal Ca2+-binding domain

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Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

21 January 2018

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The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

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Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

21 January 2018

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Preference of calcium‐dependent interactions between calmodulin‐like domains of calpain and calpastatin subdomains

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Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors

21 January 2018

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Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine

21 January 2018

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Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunit

21 January 2018

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Calpain and caspase: can you tell the difference?

21 January 2018

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The calpain small subunit gene is essential: its inactivation results in embryonic lethality.

21 January 2018

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