Complete Switch of Reaction Specificity of an Aldolase by Directed Evolution In Vitro: Synthesis of Generic Aliphatic Aldol Products (Q56889074)

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30 March 2020

title

Complete Switch of Reaction Specificity of an Aldolase by Directed Evolution In Vitro: Synthesis of Generic Aliphatic Aldol Products (English)

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30 March 2020

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4

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30 March 2020

Wolf-Dieter Fessner

5

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30 March 2020

author name string

Sebastian Junker

1

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30 March 2020

Raquel Roldan

2

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30 March 2020

Henk-Jan Joosten

3

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30 March 2020

language of work or name

English

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publication date

4 July 2018

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Angewandte Chemie International Edition

30 March 2020

published in

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30 March 2020

volume

57

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30 March 2020

issue

32

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30 March 2020

page(s)

10153-10157

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Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase

30 March 2020

cites work

1 reference

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CorNet: Assigning function to networks of co-evolving residues by automated literature mining

2 November 2018

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Breaking the Dogma of Aldolase Specificity: Simple Aliphatic Ketones and Aldehydes are Nucleophiles for Fructose-6-phosphate Aldolase

2 November 2018

1 reference

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Converting Transaldolase into Aldolase through Swapping of the Multifunctional Acid-Base Catalyst: Common and Divergent Catalytic Principles in F6P Aldolase and Transaldolase

2 November 2018

1 reference

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Engineering aldolases as biocatalysts

2 November 2018

1 reference

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Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.

2 November 2018

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Use of 'small but smart' libraries to enhance the enantioselectivity of an esterase from Bacillus stearothermophilus towards tetrahydrofuran-3-yl acetate

2 November 2018

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Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism

2 November 2018

1 reference

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The transaldolase family: new synthetic opportunities from an ancient enzyme scaffold

2 November 2018

1 reference

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C-C bond-forming lyases in organic synthesis

2 November 2018

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Broadening deoxysugar glycodiversity: natural and engineered transaldolases unlock a complementary substrate space.

2 November 2018

1 reference

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Biosynthesis of polyketides by trans-AT polyketide synthases

2 November 2018

1 reference

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3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities.

2 November 2018

1 reference

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Recent progress in stereoselective synthesis with aldolases

2 November 2018

1 reference

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Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by D-fructose-6-phosphate aldolase.

2 November 2018

1 reference

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D-fructose-6-phosphate aldolase in organic synthesis: cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds

2 November 2018

1 reference

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GLUE-IT and PEDEL-AA: new programmes for analyzing protein diversity in randomized libraries

2 November 2018

1 reference

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Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms

2 November 2018

1 reference

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D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols.

2 November 2018

1 reference

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Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase.

2 November 2018

1 reference

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Crystal structure of decameric fructose-6-phosphate aldolase from Escherichia coli reveals inter-subunit helix swapping as a structural basis for assembly differences in the transaldolase family

2 November 2018

1 reference

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Identification of catalytically important residues in the active site of Escherichia coli transaldolase

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6099348

Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6099348

Fructose-6-phosphate Aldolase in Organic Synthesis: Preparation ofd-Fagomine,N-Alkylated Derivatives, and Preliminary Biological Assays

2 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29882622

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ANIE.201804831

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29882622%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

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30 March 2020

PubMed publication ID

29882622

1 reference