IL-27 inhibits the development of regulatory T cells via STAT3 (Q56900809)

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Vera Steinwald

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Anna Guralnik

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Anne Brüstle

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Peter Kleemann

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Christine Rosenplänter

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Thomas Decker

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Michael Lohoff

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

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language of work or name

English

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publication date

February 2008

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published in

International Immunology

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volume

20

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issue

2

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page(s)

223-34

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cites work

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

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IL-27 limits IL-2 production during Th1 differentiation.

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The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

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Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

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T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

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Foxp3-dependent programme of regulatory T-cell differentiation

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