Genetics of type 1 diabetes (Q56903501)

Endocrinology and Metabolism Clinics of North America

Europe PubMed Central

title

Genetics of type 1 diabetes (English)

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Alberto Pugliese

1

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language of work or name

English

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publication date

March 2004

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published in

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volume

33

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issue

1

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page(s)

1-16, vii

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cites work

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Mapping genes for autoimmunity in humans: type 1 diabetes as a model

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Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family

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A genome-wide search for human type 1 diabetes susceptibility genes

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A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

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A search for type 1 diabetes susceptibility genes in families from the United Kingdom

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Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families

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HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review

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Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children

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HL-A antigens and diabetes mellitus.

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Association between type 1 diabetes age of onset and HLA among sibling pairs.

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A new marker in the HLA class I region is associated with the age at onset of IDDM

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A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group

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Variation in HLA-associated risks of childhood insulin-dependent diabetes in the Finnish population: I. Allele effects at A, B, and DR loci. DiMe Study Group. Childhood Diabetes in Finland

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The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene

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Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetes

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Contribution of MIC-A polymorphism to type 1 diabetes mellitus in Basques

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MHC class I chain-related gene alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offspring in HBDI families

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In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes

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HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

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HLA-DQB1 codon 57 is critical for peptide binding and recognition.

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The combination of several polymorphic amino acid residues in the DQalpha and DQbeta chains forms a domain structure pattern and is associated with insulin-dependent diabetes mellitus

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A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus

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Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

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Limited loss of tolerance to islet autoantigens in ICA+ first degree relatives of patients with type I diabetes expressing the HLA dqb1*0602 allele

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The insulin gene in diabetes

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Concordance for type 1 diabetes in identical twins is affected by insulin genotype

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The paternally inherited insulin gene B allele (1,428 FokI site) confers protection from insulin-dependent diabetes in families

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IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus

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Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

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Allele diversity and germline mutation at the insulin minisatellite

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Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes

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A consensus repeat sequence from the human insulin gene linked polymorphic region adopts multiple quadriplex DNA structures in vitro

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Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

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7 January 2021

Peripheral antigen-expressing cells and autoimmunity

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Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

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Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

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The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

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Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

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Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population

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7 January 2021

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33

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7 January 2021

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

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7 January 2021

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

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7 January 2021

Preferential transmission of diabetic alleles within the HLA gene complex

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7 January 2021

Excess of maternal HLA-DR3 antigens in HLA DR3,4 positive Type 1 (insulin-dependent) diabetic patients

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7 January 2021

What good is genomic imprinting: the function of parent-specific gene expression

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7 January 2021

Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

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7 January 2021

Evidence that insulin is imprinted in the human yolk sac

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7 January 2021

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

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7 January 2021

Paramutation and related allelic interactions

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7 January 2021

Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.

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7 January 2021

Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen

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7 January 2021