Pharmacophore modeling and parallel screening for PPAR ligands (Q57010606)

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Thierry Langer

object named as

Thierry Langer

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author name string

Patrick Markt

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Christian Laggner

Journal of Computer - Aided Molecular Design

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publication date

October 2007

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published in

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volume

21

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issue

10-11

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page(s)

575-590

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cites work

Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity.

1 reference

12 December 2020

PPAR‐α and ‐γ but not ‐δ agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF‐κB‐independent effect

1 reference

12 December 2020

The PPARs: from orphan receptors to drug discovery

1 reference

12 December 2020

Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.

1 reference

12 December 2020

The Protein Data Bank

1 reference

12 December 2020

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies

1 reference

12 December 2020

Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model

1 reference

12 December 2020

Design and synthesis of potent and subtype-selective PPARalpha agonists.

1 reference

12 December 2020

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

1 reference

12 December 2020

Influenza virus neuraminidase inhibitors: generation and comparison of structure-based and common feature pharmacophore hypotheses and their application in virtual screening.

1 reference

12 December 2020

Pharmacophore identification and 3D-QSAR studies in N-(2-benzoyl phenyl)-L-tyrosines as PPAR gamma agonists

1 reference

12 December 2020

Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione

1 reference

12 December 2020

Pharmacophore modeling, docking, and principal component analysis based clustering: combined computer-assisted approaches to identify new inhibitors of the human rhinovirus coat protein.

1 reference

12 December 2020

Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar

1 reference

12 December 2020

Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons

1 reference

12 December 2020

Kinases, Homology Models, and High Throughput Docking

1 reference

12 December 2020

Pharmacophore modeling and in silico screening for new P450 19 (aromatase) inhibitors

1 reference

12 December 2020

A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects

1 reference

12 December 2020

Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity

1 reference

12 December 2020

1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists

1 reference

12 December 2020

Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes

1 reference

12 December 2020

(2R)-2-methylchromane-2-carboxylic acids: discovery of selective PPARalpha agonists as hypolipidemic agents

1 reference

12 December 2020

Development and Validation of an In Silico P450 Profiler Based on Pharmacophore Models

1 reference

12 December 2020

Use of catalyst pharmacophore models for screening of large combinatorial libraries

1 reference

12 December 2020

Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats

1 reference

12 December 2020

Parallel Screening: A Novel Concept in Pharmacophore Modeling and Virtual Screening†

1 reference

12 December 2020

Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity

1 reference

12 December 2020

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

1 reference

12 December 2020

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

1 reference

12 December 2020

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

1 reference

12 December 2020

Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.

1 reference

12 December 2020

Improving structure-based virtual screening by multivariate analysis of scoring data

1 reference

12 December 2020

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

1 reference

12 December 2020

In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases,

1 reference

12 December 2020

Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype

1 reference

12 December 2020

A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro

1 reference

12 December 2020

Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.

1 reference

12 December 2020

Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight

1 reference

12 December 2020

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

1 reference

12 December 2020

10.1007/S10822-007-9140-0

Identifiers

DOI

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DBLP publication ID

journals/jcamd/MarktSKLL07

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DBLP Dataset 2021-01-02