Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development (Q57198364)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8624804%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

title

Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development (English)

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15 October 2019

3

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15 October 2019

Klaus Rajewsky

series ordinal

4

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15 October 2019

author name string

D Löffert

series ordinal

1

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15 October 2019

A Ehlich

series ordinal

2

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15 October 2019

language of work or name

English

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publication date

1 February 1996

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15 October 2019

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15 October 2019

volume

4

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15 October 2019

issue

2

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15 October 2019

page(s)

133-144

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Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

15 October 2019

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Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

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Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

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7 January 2021

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation

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7 January 2021

B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames

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Most peripheral B cells in mice are ligand selected

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Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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7 January 2021

Influence of surrogate L chain on DHJH-reading frame 2 suppression in mouse precursor B cells.

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7 January 2021

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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7 January 2021

Only DFL16, DSP2, and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which DFL16 and DSP2 originate from the same primordial DH gene

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7 January 2021

Reading of D genes in variable frames as a source of antibody diversity

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7 January 2021

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain

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7 January 2021

The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

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7 January 2021

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

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7 January 2021

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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7 January 2021

A critical role of λ5 protein in B cell development

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7 January 2021

Immunoglobulin chain loss in hybridoma lines

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7 January 2021

Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

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7 January 2021

A high frequency of hybridomas from M54 mu heavy chain transgenic mice initially co-express transgenic and rearranged endogenous mu genes

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7 January 2021

The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the protection

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7 January 2021

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

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7 January 2021

C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon

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7 January 2021

Monoclonal antibodies specific for murine IgM I. Characterization of antigenic determinants on the four constant domains of the μ heavy chain

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7 January 2021

Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

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7 January 2021

V(D)J recombination and the cell cycle.

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7 January 2021

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains

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7 January 2021

Analysis of junctional diversity during B lymphocyte development

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7 January 2021

High gradient magnetic cell separation with MACS

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7 January 2021

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins

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7 January 2021

Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

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7 January 2021

Allelic exclusion model questioned

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7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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7 January 2021

The role of Ig beta in precursor B cell transition and allelic exclusion

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7 January 2021

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

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7 January 2021

Early and late B-cell development in the mouse

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7 January 2021

Allelic exclusion model questioned

1 reference

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7 January 2021

B-lineage cells in mu-transgenic scid mice proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement

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7 January 2021

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

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7 January 2021

Regulated progression of a cultured pre-B-cell line to the B-cell stage.

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7 January 2021

Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice

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7 January 2021

Molecular and cellular origins of B lymphocyte diversity

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7 January 2021

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

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7 January 2021

The V(D)J recombination activating gene, RAG-1.

1 reference

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7 January 2021

Monoclonal anti-allotype antibody towards BALB/c IgM. Analysis of specificity and site of a V-C crossover in recombinant strain BALB-Igh-Va/Igh-Cb

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7 January 2021

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

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7 January 2021

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

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7 January 2021

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.

1 reference

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7 January 2021

Somatic generation of antibody diversity

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7 January 2021

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface

1 reference

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7 January 2021

Cell surface expression of the short immunoglobulin mu chain (D mu protein) in murine pre-B cells is differently regulated from that of the intact mu chain

1 reference

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7 January 2021

Crosslinking of the cell surface immunoglobulin (mu-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin kappa locus

1 reference

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7 January 2021

Initiation of V(D)J recombination in a cell-free system.

1 reference

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7 January 2021

A theory of allelic and isotypic exclusion for immunoglobulin genes

1 reference

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7 January 2021

Allelic exclusion model questioned

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980678-0

7 January 2021

Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene

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7 January 2021

A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes.

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7 January 2021

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response

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7 January 2021

Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface

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7 January 2021

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation

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7 January 2021

10.1016/S1074-7613(00)80678-0

Identifiers

DOI

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15 October 2019

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