Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis (Q57250932)

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1 February 2020

title

Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis (English)

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1

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Fernando Rivadeneira

9

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Clemens van Blitterswijk

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A Hofman

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J van Meurs

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author name string

J Emons

2

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C Sticht

3

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S van Gool

4

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E Decker

5

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A Uitterlinden

6

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G Rappold

7

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S Scherjon

10

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J M Wit

11

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M Karperien

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publication date

1 October 2012

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1 February 2020

published in

Arthritis and Rheumatism

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volume

64

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issue

10

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page(s)

3302-3312

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Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.

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cites work

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Dual function of β-catenin in articular cartilage growth and degeneration at different stages of postnatal cartilage development

21 January 2018

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Regulation of growth plate chondrogenesis by bone morphogenetic protein-2.

21 January 2018

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Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

21 January 2018

1 reference

Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes.

21 January 2018

1 reference

Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.

21 January 2018

1 reference

Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts

21 January 2018

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Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

21 January 2018

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A rapid and efficient method for expansion of human mesenchymal stem cells.

21 January 2018

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Endochondral bone tissue engineering using embryonic stem cells

21 January 2018

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Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway.

21 January 2018

1 reference

Dexamethasone increases growth hormone receptor messenger ribonucleic acid levels in liver and growth plate.

21 January 2018

1 reference

GenMAPP 2: new features and resources for pathway analysis

21 January 2018

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PANTHER: a library of protein families and subfamilies indexed by function

21 January 2018

1 reference

The Rotterdam Study: 2012 objectives and design update

21 January 2018

1 reference

PLINK: a tool set for whole-genome association and population-based linkage analyses

21 January 2018

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Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

21 January 2018

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Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro

21 January 2018

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Growth factor combination for chondrogenic induction from human mesenchymal stem cell.

21 January 2018

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Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

21 January 2018

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Gradients in bone morphogenetic protein-related gene expression across the growth plate.

21 January 2018

1 reference

New insights into osteoarthritis: early developmental features of an ageing-related disease.

21 January 2018

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Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy.

21 January 2018

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Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

21 January 2018

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Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

21 January 2018

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Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction

21 January 2018

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WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

21 January 2018

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Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

21 January 2018

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Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.34535

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1 February 2020

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