Phosphorylation of the Transactivation Domain of Pax6 by Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinase (Q57271959)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10329718%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

title

Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (English)

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8 December 2019

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1

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8 December 2019

Jack-Ansgar Bruun

2

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8 December 2019

Terje Johansen

5

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8 December 2019

author name string

G Bjorkoy

3

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8 December 2019

T Holm

4

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8 December 2019

language of work or name

English

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publication date

1 May 1999

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Journal of Biological Chemistry

8 December 2019

published in

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8 December 2019

volume

274

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8 December 2019

issue

21

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8 December 2019

page(s)

15115-15126

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8 December 2019

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https://api.crossref.org/works/10.1074%2FJBC.274.21.15115

Evolution and role of Pax genes

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Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

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PAX-6 in development and evolution

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Expression pattern of zebrafish pax genes suggests a role in early brain regionalization

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Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells

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Multiple functions for Pax6 in mouse eye and nasal development.

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Pax6: more than meets the eye.

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Mouse small eye results from mutations in a paired-like homeobox-containing gene

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New perspectives on eye evolution

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Isolation of a Pax-6 homolog from the ribbonworm Lineus sanguineus

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Zebrafish contains two pax6 genes involved in eye development

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Squid Pax-6 and eye development

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DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

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Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations

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High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA

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DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5).

21 January 2018

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PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

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Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6.

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Characterization of quail Pax-6 (Pax-QNR) proteins expressed in the neuroretina

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Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

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Regulation of transcription by MAP kinase cascades

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Mitogen-activated protein kinase pathways

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Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

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MAP kinase binds to the NH2-terminal activation domain of c-Myc

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

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Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

21 January 2018

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MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction

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The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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The stress-activated protein kinase subfamily of c-Jun kinases

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Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

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Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

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Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

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BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

21 January 2018

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Transcription factor ATF2 regulation by the JNK signal transduction pathway

21 January 2018

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Zebrafish Pax9 encodes two proteins with distinct C-terminal transactivating domains of different potency negatively regulated by adjacent N-terminal sequences

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Methods for analyzing c-Jun kinase

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Reversion of Ras- and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase C lambda is accompanied by the loss of constitutive nuclear mitogen-activated protein k

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Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

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Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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The paired domain-containing nuclear factor pax[b] is expressed in specific commissural interneurons in zebrafish embryos

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Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

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Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.

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Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing

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Pax-3 contains domains for transcription activation and transcription inhibition

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The regulation of transcription by phosphorylation

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Truncation mutations in the transactivation region of PAX6 result in dominant-negative mutants

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Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia.

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Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity

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MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.21.15115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10329718%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference