Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL (Q57272579)

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18 January 2020

title

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL (English)

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18 January 2020

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4

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18 January 2020

Joseph A. Trapani

5

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18 January 2020

author name string

Mark D McKenzie

1

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18 January 2020

Nadine L Dudek

2

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18 January 2020

Lina Mariana

3

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18 January 2020

Helen E Thomas

7

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18 January 2020

Thomas Wh Kay

6

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18 January 2020

publication date

30 March 2006

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18 January 2020

published in

International Immunology

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18 January 2020

volume

18

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18 January 2020

page(s)

837-846

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issue

6

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beta-Cell death during progression to diabetes

18 January 2020

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The beta cell in autoimmune diabetes: many mechanisms and pathways of loss

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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

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CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity

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Helper requirements for generation of effector CTL to islet beta cell antigens.

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

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How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

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Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

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Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

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Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice

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Contribution of Fas to diabetes development

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Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

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Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes

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Mouse islet cell lysis mediated by interleukin-1-induced Fas.

21 January 2018

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Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice

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Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1.

21 January 2018

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Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production

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An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1?

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Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice

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Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

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The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis

21 January 2018

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IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes

21 January 2018

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

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21 January 2018

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21 January 2018

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Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/INTIMM/DXL020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16574667%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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